Protein synthesis regulation, a pillar of strength for innate immunity?

Highlights • Protein synthesis regulation is required to mount efficient immune responses. • Microbial recognition regulates protein synthesis. • Sensing protein synthesis variation allows microbial recognition by host cells. • eIF2-kinases and the mTOR pathways are central to immunity and microbial...

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Veröffentlicht in:	Current opinion in immunology 2015-02, Vol.32, p.28-35
Hauptverfasser:	Argüello, Rafael J, Rodrigues, Christian Rodriguez, Gatti, Evelina, Pierre, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen Presentation - immunology Cell Nucleus - genetics Cell Nucleus - metabolism Gene Expression Regulation Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Humans Immunity, Innate Infection - genetics Infection - immunology Infection - metabolism Peptide Chain Initiation, Translational Protein Biosynthesis Receptors, Pattern Recognition - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Protein synthesis regulation is required to mount efficient immune responses. • Microbial recognition regulates protein synthesis. • Sensing protein synthesis variation allows microbial recognition by host cells. • eIF2-kinases and the mTOR pathways are central to immunity and microbial detection. • Antigen presentation is dependent on protein synthesis and its sub-cellular location.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2014.12.001