Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease

Highlights • We built a APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease. • The two main areas where neurogenesis was seen are the DG-SGZ and LV-SVZ. • AD temporally impairs hippocampal neurogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-02, Vol.314, p.64-74
Hauptverfasser:	Zeng, Q, Zheng, M, Zhang, T, He, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer’s disease Amyloid beta-Protein Precursor - genetics Animals Dendritic Spines Disease Models, Animal Female Green Fluorescent Proteins - genetics hippocampal neurogenesis Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans Male Mice Mice, Transgenic Nestin - genetics neural progenitors neurodegeneration Neurogenesis Neurology Neurons - metabolism Neurons - pathology Presenilin-1 - genetics
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Beschreibung
Zusammenfassung:	Highlights • We built a APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease. • The two main areas where neurogenesis was seen are the DG-SGZ and LV-SVZ. • AD temporally impairs hippocampal neurogenesis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.11.054