Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)- alpha production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF alpha . The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Plasma growth hormone, TNF alpha , CRP, IL-6, IL1- beta , IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents. Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF alpha levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF alpha levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines.