Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2)

Highlights • A2A R activates pERK1/2 in a DAG-dependent pathway in a cerebral IR model. • SCH58261 protects against cerebral IR by inhibiting pERK1/2 in hippocampal neurons. • SCH58261 and PD98059 decrease excitotoxicity, inflammatory and apoptotic mediators.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-02, Vol.314, p.145-159
Hauptverfasser:	Mohamed, R.A, Agha, A.M, Abdel-Rahman, A.A, Nassar, N.N
Format:	Artikel
Sprache:	eng
Schlagworte:	A2A Adenosine A2 Receptor Antagonists - administration & dosage Animals apoptosis Apoptosis - drug effects Brain Ischemia - metabolism Brain-Derived Neurotrophic Factor - metabolism Cyclic AMP - metabolism Flavonoids - administration & dosage Hippocampus - drug effects Hippocampus - pathology Inflammation Mediators - metabolism ischemia reperfusion Male MAP Kinase Signaling System Maze Learning - drug effects Maze Learning - physiology microglia Microglia - drug effects Microglia - metabolism Motor Activity - drug effects Neurology oxidative stress pERK1/2 Phosphorylation Pyrimidines - administration & dosage Rats Rats, Wistar Receptor, Adenosine A2A - metabolism Reperfusion Injury - metabolism Triazoles - administration & dosage
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Beschreibung
Zusammenfassung:	Highlights • A2A R activates pERK1/2 in a DAG-dependent pathway in a cerebral IR model. • SCH58261 protects against cerebral IR by inhibiting pERK1/2 in hippocampal neurons. • SCH58261 and PD98059 decrease excitotoxicity, inflammatory and apoptotic mediators.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.11.059