Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis

ARV1 is involved in regulating lipid homeostasis but also in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. Here, we examined whether human ARV1 can complement the role of yeast ARV1 in GPI biosynthesis. Overexpression of human ARV1 could rescue the phenotypes as...

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Veröffentlicht in:	Yeast (Chichester, England) England), 2016-02, Vol.33 (2), p.37-42
Hauptverfasser:	Ikeda, Atsuko, Kajiwara, Kentaro, Iwamoto, Kunihiko, Makino, Asami, Kobayashi, Toshihide, Mizuta, Keiko, Funato, Kouichi
Format:	Artikel
Sprache:	eng
Schlagworte:	arv1Δ mutant Carrier Proteins - genetics Carrier Proteins - metabolism complementation Gene Expression Genetic Complementation Test Glycosylphosphatidylinositols - biosynthesis GPI anchor Homeostasis human ARV1 Humans Lipid Metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism yeast
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