Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis
ARV1 is involved in regulating lipid homeostasis but also in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. Here, we examined whether human ARV1 can complement the role of yeast ARV1 in GPI biosynthesis. Overexpression of human ARV1 could rescue the phenotypes as...
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| Veröffentlicht in: | Yeast (Chichester, England) England), 2016-02, Vol.33 (2), p.37-42 |
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| container_title | Yeast (Chichester, England) |
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| creator | Ikeda, Atsuko Kajiwara, Kentaro Iwamoto, Kunihiko Makino, Asami Kobayashi, Toshihide Mizuta, Keiko Funato, Kouichi |
| description | ARV1 is involved in regulating lipid homeostasis but also in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. Here, we examined whether human ARV1 can complement the role of yeast ARV1 in GPI biosynthesis. Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Δ mutant. The results suggest that Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. Copyright © 2015 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/yea.3138 |
| format | Article |
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| subjects | arv1Δ mutant Carrier Proteins - genetics Carrier Proteins - metabolism complementation Gene Expression Genetic Complementation Test Glycosylphosphatidylinositols - biosynthesis GPI anchor Homeostasis human ARV1 Humans Lipid Metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism yeast |
| title | Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis |
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