Comparison of the Efficacy of Everolimus-Eluting Stents Versus Drug-Eluting Balloons in Patients With In-Stent Restenosis (from the RIBS IV and V Randomized Clinical Trials)

Treatment of patients with in-stent restenosis (ISR) remains a challenge. This study sought to compare the efficacy of everolimus-eluting stents (EESs) and drug-eluting balloons (DEBs) with paclitaxel in patients with ISR. A pooled analysis of the Restenosis Intra-Stent of Drug-Eluting Stents: Drug-...

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Veröffentlicht in:	The American journal of cardiology 2016-02, Vol.117 (4), p.546-554
Hauptverfasser:	Alfonso, Fernando, MD, Pérez-Vizcayno, María José, MD, García del Blanco, Bruno, MD, García-Touchard, Arturo, MD, Masotti, Mónica, MD, López-Minguez, José R., MD, Iñiguez, Andrés, MD, Zueco, Javier, MD, Velazquez, Maite, MD, Cequier, Angel, MD, Lázaro-García, Rosa, MD, Martí, Vicens, MD, Moris, César, MD, Urbano-Carrillo, Cristobal, MD, Bastante, Teresa, MD, Rivero, Fernando, MD, Cárdenas, Alberto, MD, Gonzalo, Nieves, MD, Jiménez-Quevedo, Pilar, MD, Fernández, Cristina, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angioplasty Angioplasty, Balloon, Coronary - instrumentation Cardiology Cardiovascular Clinical trials Confidence intervals Coronary Angiography Coronary Restenosis - diagnostic imaging Coronary Restenosis - surgery Drug-Eluting Stents Everolimus - pharmacology Female Follow-Up Studies Graft Occlusion, Vascular - diagnostic imaging Graft Occlusion, Vascular - surgery Heart attacks Humans Immunosuppressive Agents - pharmacology Laboratories Male Percutaneous Coronary Intervention - methods Prospective Studies Prosthesis Design Stents Studies Time Factors Treatment Outcome
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Zusammenfassung:	Treatment of patients with in-stent restenosis (ISR) remains a challenge. This study sought to compare the efficacy of everolimus-eluting stents (EESs) and drug-eluting balloons (DEBs) with paclitaxel in patients with ISR. A pooled analysis of the Restenosis Intra-Stent of Drug-Eluting Stents: Drug-Eluting Balloon vs Everolimus-Eluting Stent (RIBS IV) and Restenosis Intra-Stent of Bare-Metal Stents: Drug-Eluting Balloon vs Everolimus-Eluting Stent (RIBS V) randomized trials was performed using patient-level data. In both trials, EESs were compared with DEBs in patients with ISR (RIBS V included 189 patients with bare-metal ISR; RIBS IV included 309 patients with drug-eluting ISR). Inclusion and exclusion criteria were identical in both trials. A total of 249 patients were allocated to EES and 249 to DEB. Clinical follow-up at 1 year was obtained in all (100%) patients and late angiography (median 249 days) in 91% of eligible patients. Compared with patients treated with DEBs, patients treated with EESs obtained better short-term results (postprocedural minimal lumen diameter 2.28 ± 0.5 vs 2.12 ± 0.4 mm, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2015.11.042