Orexins cause epileptic activity
► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats. Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects o...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-09, Vol.37 (1), p.161-164 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Erken, Haydar Ali Erken, Gülten Genç, Osman Kortunay, Selim Şahiner, Melike Turgut, Günfer Turgut, Sebahat |
| description | ► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats.
Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. |
| doi_str_mv | 10.1016/j.peptides.2012.06.012 |
| format | Article |
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Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2012.06.012</identifier><identifier>PMID: 22771311</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analgesia ; Animals ; Control ; Disease Models, Animal ; Drinking ; EEG ; Electroencephalography ; energy ; Epilepsy ; Epilepsy - chemically induced ; Epilepsy - physiopathology ; Homeostasis ; Hypocretin ; Injections, Intraventricular ; Intracellular Signaling Peptides and Proteins - administration & dosage ; Intracellular Signaling Peptides and Proteins - adverse effects ; Learning ; Male ; memory ; Neuropeptides - administration & dosage ; Neuropeptides - adverse effects ; Neurotransmitter Agents - administration & dosage ; Neurotransmitter Agents - adverse effects ; Orexin ; Orexins ; Peptides ; Power spectrum ; Rats ; Rats, Wistar ; Seizing ; Seizure</subject><ispartof>Peptides (New York, N.Y. : 1980), 2012-09, Vol.37 (1), p.161-164</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-2b3de3d7fd4c44781838af4656fb10fe88c5c0778642a884ae7c425d6e16a6163</citedby><cites>FETCH-LOGICAL-c458t-2b3de3d7fd4c44781838af4656fb10fe88c5c0778642a884ae7c425d6e16a6163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.peptides.2012.06.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22771311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erken, Haydar Ali</creatorcontrib><creatorcontrib>Erken, Gülten</creatorcontrib><creatorcontrib>Genç, Osman</creatorcontrib><creatorcontrib>Kortunay, Selim</creatorcontrib><creatorcontrib>Şahiner, Melike</creatorcontrib><creatorcontrib>Turgut, Günfer</creatorcontrib><creatorcontrib>Turgut, Sebahat</creatorcontrib><title>Orexins cause epileptic activity</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats.
Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Control</subject><subject>Disease Models, Animal</subject><subject>Drinking</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>energy</subject><subject>Epilepsy</subject><subject>Epilepsy - chemically induced</subject><subject>Epilepsy - physiopathology</subject><subject>Homeostasis</subject><subject>Hypocretin</subject><subject>Injections, Intraventricular</subject><subject>Intracellular Signaling Peptides and Proteins - administration & dosage</subject><subject>Intracellular Signaling Peptides and Proteins - adverse effects</subject><subject>Learning</subject><subject>Male</subject><subject>memory</subject><subject>Neuropeptides - administration & dosage</subject><subject>Neuropeptides - adverse effects</subject><subject>Neurotransmitter Agents - administration & dosage</subject><subject>Neurotransmitter Agents - adverse effects</subject><subject>Orexin</subject><subject>Orexins</subject><subject>Peptides</subject><subject>Power spectrum</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizing</subject><subject>Seizure</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1PwzAQhi0EoqXwF0pHlgRf7NjOBkJ8SZU6QGfLdS7IVdoEO63ov8dVWtYyvctz752eI2QMNAUK4n6Ztth2rsSQZhSylIo0xhkZgpIsyUEU52RIoRBJIRUMyFUIS0op54W6JIMskxIYwJBMZh5_3DpMrNkEnGDr6n2vnRjbua3rdtfkojJ1wJtDjsj85fnz6S2Zzl7fnx6nieW56pJswUpkpaxKbjmPKxVTpuIiF9UCaIVK2dxSKZXgmVGKG5SWZ3kpEIQRINiI3PW9rW--Nxg6vXLBYl2bNTaboEGKDDgTIE-jOQPKGP8PSlkOVBZcRVT0qPVNCB4r3Xq3Mn4XIb13rpf66FzvnWsqdIw4OD7s2CxWWP6NHSVH4LYHKtNo8-Vd0POP2CDiQ2gh8yISDz2B0fDWodfBOlxbLJ1H2-mycaeu-AWCFZxO</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Erken, Haydar Ali</creator><creator>Erken, Gülten</creator><creator>Genç, Osman</creator><creator>Kortunay, Selim</creator><creator>Şahiner, Melike</creator><creator>Turgut, Günfer</creator><creator>Turgut, Sebahat</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20120901</creationdate><title>Orexins cause epileptic activity</title><author>Erken, Haydar Ali ; Erken, Gülten ; Genç, Osman ; Kortunay, Selim ; Şahiner, Melike ; Turgut, Günfer ; Turgut, Sebahat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-2b3de3d7fd4c44781838af4656fb10fe88c5c0778642a884ae7c425d6e16a6163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Control</topic><topic>Disease Models, Animal</topic><topic>Drinking</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>energy</topic><topic>Epilepsy</topic><topic>Epilepsy - chemically induced</topic><topic>Epilepsy - physiopathology</topic><topic>Homeostasis</topic><topic>Hypocretin</topic><topic>Injections, Intraventricular</topic><topic>Intracellular Signaling Peptides and Proteins - administration & dosage</topic><topic>Intracellular Signaling Peptides and Proteins - adverse effects</topic><topic>Learning</topic><topic>Male</topic><topic>memory</topic><topic>Neuropeptides - administration & dosage</topic><topic>Neuropeptides - adverse effects</topic><topic>Neurotransmitter Agents - administration & dosage</topic><topic>Neurotransmitter Agents - adverse effects</topic><topic>Orexin</topic><topic>Orexins</topic><topic>Peptides</topic><topic>Power spectrum</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizing</topic><topic>Seizure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erken, Haydar Ali</creatorcontrib><creatorcontrib>Erken, Gülten</creatorcontrib><creatorcontrib>Genç, Osman</creatorcontrib><creatorcontrib>Kortunay, Selim</creatorcontrib><creatorcontrib>Şahiner, Melike</creatorcontrib><creatorcontrib>Turgut, Günfer</creatorcontrib><creatorcontrib>Turgut, Sebahat</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erken, Haydar Ali</au><au>Erken, Gülten</au><au>Genç, Osman</au><au>Kortunay, Selim</au><au>Şahiner, Melike</au><au>Turgut, Günfer</au><au>Turgut, Sebahat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orexins cause epileptic activity</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>37</volume><issue>1</issue><spage>161</spage><epage>164</epage><pages>161-164</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats.
Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22771311</pmid><doi>10.1016/j.peptides.2012.06.012</doi><tpages>4</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 2012-09, Vol.37 (1), p.161-164 |
| issn | 0196-9781 1873-5169 |
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| subjects | Analgesia Animals Control Disease Models, Animal Drinking EEG Electroencephalography energy Epilepsy Epilepsy - chemically induced Epilepsy - physiopathology Homeostasis Hypocretin Injections, Intraventricular Intracellular Signaling Peptides and Proteins - administration & dosage Intracellular Signaling Peptides and Proteins - adverse effects Learning Male memory Neuropeptides - administration & dosage Neuropeptides - adverse effects Neurotransmitter Agents - administration & dosage Neurotransmitter Agents - adverse effects Orexin Orexins Peptides Power spectrum Rats Rats, Wistar Seizing Seizure |
| title | Orexins cause epileptic activity |
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