Orexins cause epileptic activity

► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats. Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects o...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-09, Vol.37 (1), p.161-164
Hauptverfasser:	Erken, Haydar Ali, Erken, Gülten, Genç, Osman, Kortunay, Selim, Şahiner, Melike, Turgut, Günfer, Turgut, Sebahat
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Control Disease Models, Animal Drinking EEG Electroencephalography energy Epilepsy Epilepsy - chemically induced Epilepsy - physiopathology Homeostasis Hypocretin Injections, Intraventricular Intracellular Signaling Peptides and Proteins - administration & dosage Intracellular Signaling Peptides and Proteins - adverse effects Learning Male memory Neuropeptides - administration & dosage Neuropeptides - adverse effects Neurotransmitter Agents - administration & dosage Neurotransmitter Agents - adverse effects Orexin Orexins Peptides Power spectrum Rats Rats, Wistar Seizing Seizure
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Zusammenfassung:	► Orexins are excitatory neuropeptides. ► Orexins were intracortically applied to rats. ► Orexins cause epileptic activity in rats. Orexins have been implicated in the regulation of sleep–wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100pmol) and B (100pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/j.peptides.2012.06.012