Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

A mild one-pot methodology has been developed to deracemise rac - 2 -phenyl-1-propanol by combining the use of non-selective laccase/TEMPO-mediated oxidation with enantioselective bioreduction of the racemic aldehyde intermediate under dynamic conditions. The process was easily scalable and stereoco...

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Veröffentlicht in:Catalysis science & technology 2015-03, Vol.5 (3), p.1443-1446
Hauptverfasser: Díaz-Rodríguez, Alba, Ríos-Lombardía, Nicolás, Sattler, Johann H., Lavandera, Iván, Gotor-Fernández, Vicente, Kroutil, Wolfgang, Gotor, Vicente
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Aldehydes
Catalysis
Dynamics
Laccase
Methodology
Oxidation
Reaction kinetics
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Zusammenfassung:A mild one-pot methodology has been developed to deracemise rac - 2 -phenyl-1-propanol by combining the use of non-selective laccase/TEMPO-mediated oxidation with enantioselective bioreduction of the racemic aldehyde intermediate under dynamic conditions. The process was easily scalable and stereocontrollable by selecting the suitable biocatalyst.
ISSN:2044-4753
2044-4761
DOI:10.1039/C4CY01351D