Directed Self-Assembly of Lipid Nanotubes from Inverted Hexagonal Structures

Directed Self-Assembly of Lipid Nanotubes from Inverted Hexagonal Structures

Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to p...

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Veröffentlicht in:ACS nano 2012-08, Vol.6 (8), p.6626-6632
Hauptverfasser: Sugihara, Kaori, Chami, Mohamed, Derényi, Imre, Vörös, János, Zambelli, Tomaso
Format: Artikel
Sprache:eng
Schlagworte:
Body Fluids - chemistry
Buffer solutions
Crystallization - methods
Dopes
Lamellar structure
Lipids
Materials Testing
Microfluidics - methods
Micrometers
Molecular Conformation
Nanotubes
Nanotubes - chemistry
Nanotubes - ultrastructure
Particle Size
Phosphatidylethanolamines - chemical synthesis
Self assembly
Surface Properties
Transformations
Tubes
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Zusammenfassung:Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn300557s