A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs

Abstract Background Multiple loci have been identified for coronary artery disease (CAD) by genome-wide association studies (GWAS), but no such studies on CAD incidence has been reported yet for any Middle Eastern population. Methods In this study, we performed a GWAS for CAD and myocardial infarcti...

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Veröffentlicht in:	Atherosclerosis 2016-02, Vol.245, p.62-70
Hauptverfasser:	Wakil, Salma M, Ram, Ramesh, Muiya, Nzioka P, Mehta, Munish, Andres, Editha, Mazhar, Nejat, Baz, Batoul, Hagos, Samya, Alshahid, Maie, Meyer, Brian F, Morahan, Grant, Dzimiri, Nduna
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular CDKN2A/B Coronary artery disease Coronary Artery Disease - genetics Coronary Artery Disease - metabolism CXCL12 Female Genetic Predisposition to Disease Genome-wide association Genome-Wide Association Study - methods Genotype Haplotypes Heritability Humans Incidence KCNE2 Male Middle Aged Myocardial infarction Myocardial Infarction - epidemiology Myocardial Infarction - genetics Myocardial Infarction - metabolism Risk Factors Saudi Arabia - epidemiology
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Zusammenfassung:	Abstract Background Multiple loci have been identified for coronary artery disease (CAD) by genome-wide association studies (GWAS), but no such studies on CAD incidence has been reported yet for any Middle Eastern population. Methods In this study, we performed a GWAS for CAD and myocardial infarction (MI) incidence in 5668 Saudis of Arab descent using the Affymetrix Axiom Genotyping platform. Results We describe SNPs at 16 loci that showed significant (P
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2015.11.019