Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size?
Abstract Purpose To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. Methods and Materials For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (Conv ICBT), Imag...
Gespeichert in:
| Veröffentlicht in: | Brachytherapy 2016, Vol.15 (1), p.57-64 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 64 |
|---|---|
| container_issue | 1 |
| container_start_page | 57 |
| container_title | Brachytherapy |
| container_volume | 15 |
| creator | Yoshida, Ken Yamazaki, Hideya Kotsuma, Tadayuki Takenaka, Tadashi Ueda, Mari Mikami Miyake, Shunsuke Tsujimoto, Yutaka Masui, Koji Yoshioka, Yasuo Sumida, Iori Uesugi, Yasuo Shimbo, Taiju Yoshikawa, Nobuhiko Yoshioka, Hiroto Tanaka, Eiichi Narumi, Yoshifumi |
| description | Abstract Purpose To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. Methods and Materials For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (Conv ICBT), Image-guided ICBT (IGICBT), intracavitary/interstitial brachytherapy (ICISBT), and interstitial brachytherapy (ISBT) with perineal approach] using dose-volume histograms using eight sizes of HR CTV (2 × 2 × 2 cm to 7 × 4 × 4 cm) and organs at risk model. Results InConv ICBT, the doses covered 90% of the HR CTV [ D90 (HR CTV)] decreased from 197% prescribed dose (PD) for the HR CTV size (2 × 2 × 2 cm) to 73% PD for 5 × 4 × 4 cm, whereas the other three modalities could achieve 100% PD for all HR CTV sizes. The minimum doses received by the maximally irradiated 2-cm3 volumes for organs at risks of IGICBT demonstrated lower values than those ofConv ICBT for the HR CTV size of 4 × 3 × 3 cm or smaller. ICISBT demonstrated lower values than those of IGICBT for 4 × 3 × 3 cm or larger. ISBT demonstrated lowest values for 5 × 4 × 4 cm or larger. Conclusions HR CTV size of 4 × 3 × 3 cm seems to be a threshold volume in this simulation analysis, and IGICBT is a better choice for smaller HR CTV than the threshold volume. On larger HR CTV, ICISBT or ISBT is the better choice. |
| doi_str_mv | 10.1016/j.brachy.2015.10.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1762026353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1538472115005668</els_id><sourcerecordid>1762026353</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-80fa78eeae284d1336fe4fea4ba97ac4c8c80126d6c89e1a392cb25d9a02560a3</originalsourceid><addsrcrecordid>eNqFUstu1TAQjRCIlsIfIOQlm1z8SByHBai64iVVYlFYWxN7Qn1J4mA7ReEz-GIcpbDohpVHo_PwzJmieM7ogVEmX50OXQBzsx44ZXVuHSjlD4pzphpRsqpqH-a6FqqsGs7OiicxnmimtUI8Ls64lIw3lJ4Xv6_duAyQnJ8ITDCs0UXie-Ln5Eb3Cy3ZXdINBphX0vtAloTBTUgMhltnYCAGply_JkeYyE8kEQc0iWQK6TCmewqjtzC4tBKLM07WTd9I9k7LmJVjdnz7tHjUwxDx2d17UXx9_-7L8WN59fnDp-PlVWkqJVKpaA-NQgTkqrJMCNlj1SNUHbQNmMoooyjj0kqjWmQgWm46XtsWKK8lBXFRvNx15-B_LPmjenTR4DDAhH6JmjWSUy5FLTK02qEm-BgD9noOboSwakb1loY-6X1KvaWxdXMamfbizmHpRrT_SH_XnwFvdgDmOW8dBh2Nw7xM60Jeobbe_c_hvoAZ3LSF8h1XjCe_hBxqnkVHrqm-3i5iOwhWU1pLqcQfiGm1qg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1762026353</pqid></control><display><type>article</type><title>Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size?</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yoshida, Ken ; Yamazaki, Hideya ; Kotsuma, Tadayuki ; Takenaka, Tadashi ; Ueda, Mari Mikami ; Miyake, Shunsuke ; Tsujimoto, Yutaka ; Masui, Koji ; Yoshioka, Yasuo ; Sumida, Iori ; Uesugi, Yasuo ; Shimbo, Taiju ; Yoshikawa, Nobuhiko ; Yoshioka, Hiroto ; Tanaka, Eiichi ; Narumi, Yoshifumi</creator><creatorcontrib>Yoshida, Ken ; Yamazaki, Hideya ; Kotsuma, Tadayuki ; Takenaka, Tadashi ; Ueda, Mari Mikami ; Miyake, Shunsuke ; Tsujimoto, Yutaka ; Masui, Koji ; Yoshioka, Yasuo ; Sumida, Iori ; Uesugi, Yasuo ; Shimbo, Taiju ; Yoshikawa, Nobuhiko ; Yoshioka, Hiroto ; Tanaka, Eiichi ; Narumi, Yoshifumi</creatorcontrib><description>Abstract Purpose To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. Methods and Materials For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (Conv ICBT), Image-guided ICBT (IGICBT), intracavitary/interstitial brachytherapy (ICISBT), and interstitial brachytherapy (ISBT) with perineal approach] using dose-volume histograms using eight sizes of HR CTV (2 × 2 × 2 cm to 7 × 4 × 4 cm) and organs at risk model. Results InConv ICBT, the doses covered 90% of the HR CTV [ D90 (HR CTV)] decreased from 197% prescribed dose (PD) for the HR CTV size (2 × 2 × 2 cm) to 73% PD for 5 × 4 × 4 cm, whereas the other three modalities could achieve 100% PD for all HR CTV sizes. The minimum doses received by the maximally irradiated 2-cm3 volumes for organs at risks of IGICBT demonstrated lower values than those ofConv ICBT for the HR CTV size of 4 × 3 × 3 cm or smaller. ICISBT demonstrated lower values than those of IGICBT for 4 × 3 × 3 cm or larger. ISBT demonstrated lowest values for 5 × 4 × 4 cm or larger. Conclusions HR CTV size of 4 × 3 × 3 cm seems to be a threshold volume in this simulation analysis, and IGICBT is a better choice for smaller HR CTV than the threshold volume. On larger HR CTV, ICISBT or ISBT is the better choice.</description><identifier>ISSN: 1538-4721</identifier><identifier>EISSN: 1873-1449</identifier><identifier>DOI: 10.1016/j.brachy.2015.10.002</identifier><identifier>PMID: 26612700</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Brachytherapy ; Brachytherapy - methods ; Computer Simulation ; Dose-volume histograms ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Models, Theoretical ; Organs at Risk ; Radiology ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Image-Guided - methods ; Simulation analysis ; Tumor Burden ; Uterine cervical cancer ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>Brachytherapy, 2016, Vol.15 (1), p.57-64</ispartof><rights>American Brachytherapy Society</rights><rights>2016 American Brachytherapy Society</rights><rights>Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-80fa78eeae284d1336fe4fea4ba97ac4c8c80126d6c89e1a392cb25d9a02560a3</citedby><cites>FETCH-LOGICAL-c483t-80fa78eeae284d1336fe4fea4ba97ac4c8c80126d6c89e1a392cb25d9a02560a3</cites><orcidid>0000-0003-1654-8567 ; 0000-0001-7508-7217 ; 0000-0001-9993-5575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brachy.2015.10.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26612700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshida, Ken</creatorcontrib><creatorcontrib>Yamazaki, Hideya</creatorcontrib><creatorcontrib>Kotsuma, Tadayuki</creatorcontrib><creatorcontrib>Takenaka, Tadashi</creatorcontrib><creatorcontrib>Ueda, Mari Mikami</creatorcontrib><creatorcontrib>Miyake, Shunsuke</creatorcontrib><creatorcontrib>Tsujimoto, Yutaka</creatorcontrib><creatorcontrib>Masui, Koji</creatorcontrib><creatorcontrib>Yoshioka, Yasuo</creatorcontrib><creatorcontrib>Sumida, Iori</creatorcontrib><creatorcontrib>Uesugi, Yasuo</creatorcontrib><creatorcontrib>Shimbo, Taiju</creatorcontrib><creatorcontrib>Yoshikawa, Nobuhiko</creatorcontrib><creatorcontrib>Yoshioka, Hiroto</creatorcontrib><creatorcontrib>Tanaka, Eiichi</creatorcontrib><creatorcontrib>Narumi, Yoshifumi</creatorcontrib><title>Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size?</title><title>Brachytherapy</title><addtitle>Brachytherapy</addtitle><description>Abstract Purpose To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. Methods and Materials For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (Conv ICBT), Image-guided ICBT (IGICBT), intracavitary/interstitial brachytherapy (ICISBT), and interstitial brachytherapy (ISBT) with perineal approach] using dose-volume histograms using eight sizes of HR CTV (2 × 2 × 2 cm to 7 × 4 × 4 cm) and organs at risk model. Results InConv ICBT, the doses covered 90% of the HR CTV [ D90 (HR CTV)] decreased from 197% prescribed dose (PD) for the HR CTV size (2 × 2 × 2 cm) to 73% PD for 5 × 4 × 4 cm, whereas the other three modalities could achieve 100% PD for all HR CTV sizes. The minimum doses received by the maximally irradiated 2-cm3 volumes for organs at risks of IGICBT demonstrated lower values than those ofConv ICBT for the HR CTV size of 4 × 3 × 3 cm or smaller. ICISBT demonstrated lower values than those of IGICBT for 4 × 3 × 3 cm or larger. ISBT demonstrated lowest values for 5 × 4 × 4 cm or larger. Conclusions HR CTV size of 4 × 3 × 3 cm seems to be a threshold volume in this simulation analysis, and IGICBT is a better choice for smaller HR CTV than the threshold volume. On larger HR CTV, ICISBT or ISBT is the better choice.</description><subject>Brachytherapy</subject><subject>Brachytherapy - methods</subject><subject>Computer Simulation</subject><subject>Dose-volume histograms</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Models, Theoretical</subject><subject>Organs at Risk</subject><subject>Radiology</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Radiotherapy, Image-Guided - methods</subject><subject>Simulation analysis</subject><subject>Tumor Burden</subject><subject>Uterine cervical cancer</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>1538-4721</issn><issn>1873-1449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1TAQjRCIlsIfIOQlm1z8SByHBai64iVVYlFYWxN7Qn1J4mA7ReEz-GIcpbDohpVHo_PwzJmieM7ogVEmX50OXQBzsx44ZXVuHSjlD4pzphpRsqpqH-a6FqqsGs7OiicxnmimtUI8Ls64lIw3lJ4Xv6_duAyQnJ8ITDCs0UXie-Ln5Eb3Cy3ZXdINBphX0vtAloTBTUgMhltnYCAGply_JkeYyE8kEQc0iWQK6TCmewqjtzC4tBKLM07WTd9I9k7LmJVjdnz7tHjUwxDx2d17UXx9_-7L8WN59fnDp-PlVWkqJVKpaA-NQgTkqrJMCNlj1SNUHbQNmMoooyjj0kqjWmQgWm46XtsWKK8lBXFRvNx15-B_LPmjenTR4DDAhH6JmjWSUy5FLTK02qEm-BgD9noOboSwakb1loY-6X1KvaWxdXMamfbizmHpRrT_SH_XnwFvdgDmOW8dBh2Nw7xM60Jeobbe_c_hvoAZ3LSF8h1XjCe_hBxqnkVHrqm-3i5iOwhWU1pLqcQfiGm1qg</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Yoshida, Ken</creator><creator>Yamazaki, Hideya</creator><creator>Kotsuma, Tadayuki</creator><creator>Takenaka, Tadashi</creator><creator>Ueda, Mari Mikami</creator><creator>Miyake, Shunsuke</creator><creator>Tsujimoto, Yutaka</creator><creator>Masui, Koji</creator><creator>Yoshioka, Yasuo</creator><creator>Sumida, Iori</creator><creator>Uesugi, Yasuo</creator><creator>Shimbo, Taiju</creator><creator>Yoshikawa, Nobuhiko</creator><creator>Yoshioka, Hiroto</creator><creator>Tanaka, Eiichi</creator><creator>Narumi, Yoshifumi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1654-8567</orcidid><orcidid>https://orcid.org/0000-0001-7508-7217</orcidid><orcidid>https://orcid.org/0000-0001-9993-5575</orcidid></search><sort><creationdate>2016</creationdate><title>Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size?</title><author>Yoshida, Ken ; Yamazaki, Hideya ; Kotsuma, Tadayuki ; Takenaka, Tadashi ; Ueda, Mari Mikami ; Miyake, Shunsuke ; Tsujimoto, Yutaka ; Masui, Koji ; Yoshioka, Yasuo ; Sumida, Iori ; Uesugi, Yasuo ; Shimbo, Taiju ; Yoshikawa, Nobuhiko ; Yoshioka, Hiroto ; Tanaka, Eiichi ; Narumi, Yoshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-80fa78eeae284d1336fe4fea4ba97ac4c8c80126d6c89e1a392cb25d9a02560a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Brachytherapy</topic><topic>Brachytherapy - methods</topic><topic>Computer Simulation</topic><topic>Dose-volume histograms</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Models, Theoretical</topic><topic>Organs at Risk</topic><topic>Radiology</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><topic>Radiotherapy, Image-Guided - methods</topic><topic>Simulation analysis</topic><topic>Tumor Burden</topic><topic>Uterine cervical cancer</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Ken</creatorcontrib><creatorcontrib>Yamazaki, Hideya</creatorcontrib><creatorcontrib>Kotsuma, Tadayuki</creatorcontrib><creatorcontrib>Takenaka, Tadashi</creatorcontrib><creatorcontrib>Ueda, Mari Mikami</creatorcontrib><creatorcontrib>Miyake, Shunsuke</creatorcontrib><creatorcontrib>Tsujimoto, Yutaka</creatorcontrib><creatorcontrib>Masui, Koji</creatorcontrib><creatorcontrib>Yoshioka, Yasuo</creatorcontrib><creatorcontrib>Sumida, Iori</creatorcontrib><creatorcontrib>Uesugi, Yasuo</creatorcontrib><creatorcontrib>Shimbo, Taiju</creatorcontrib><creatorcontrib>Yoshikawa, Nobuhiko</creatorcontrib><creatorcontrib>Yoshioka, Hiroto</creatorcontrib><creatorcontrib>Tanaka, Eiichi</creatorcontrib><creatorcontrib>Narumi, Yoshifumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brachytherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Ken</au><au>Yamazaki, Hideya</au><au>Kotsuma, Tadayuki</au><au>Takenaka, Tadashi</au><au>Ueda, Mari Mikami</au><au>Miyake, Shunsuke</au><au>Tsujimoto, Yutaka</au><au>Masui, Koji</au><au>Yoshioka, Yasuo</au><au>Sumida, Iori</au><au>Uesugi, Yasuo</au><au>Shimbo, Taiju</au><au>Yoshikawa, Nobuhiko</au><au>Yoshioka, Hiroto</au><au>Tanaka, Eiichi</au><au>Narumi, Yoshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size?</atitle><jtitle>Brachytherapy</jtitle><addtitle>Brachytherapy</addtitle><date>2016</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>57</spage><epage>64</epage><pages>57-64</pages><issn>1538-4721</issn><eissn>1873-1449</eissn><abstract>Abstract Purpose To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. Methods and Materials For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (Conv ICBT), Image-guided ICBT (IGICBT), intracavitary/interstitial brachytherapy (ICISBT), and interstitial brachytherapy (ISBT) with perineal approach] using dose-volume histograms using eight sizes of HR CTV (2 × 2 × 2 cm to 7 × 4 × 4 cm) and organs at risk model. Results InConv ICBT, the doses covered 90% of the HR CTV [ D90 (HR CTV)] decreased from 197% prescribed dose (PD) for the HR CTV size (2 × 2 × 2 cm) to 73% PD for 5 × 4 × 4 cm, whereas the other three modalities could achieve 100% PD for all HR CTV sizes. The minimum doses received by the maximally irradiated 2-cm3 volumes for organs at risks of IGICBT demonstrated lower values than those ofConv ICBT for the HR CTV size of 4 × 3 × 3 cm or smaller. ICISBT demonstrated lower values than those of IGICBT for 4 × 3 × 3 cm or larger. ISBT demonstrated lowest values for 5 × 4 × 4 cm or larger. Conclusions HR CTV size of 4 × 3 × 3 cm seems to be a threshold volume in this simulation analysis, and IGICBT is a better choice for smaller HR CTV than the threshold volume. On larger HR CTV, ICISBT or ISBT is the better choice.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26612700</pmid><doi>10.1016/j.brachy.2015.10.002</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1654-8567</orcidid><orcidid>https://orcid.org/0000-0001-7508-7217</orcidid><orcidid>https://orcid.org/0000-0001-9993-5575</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-4721 |
| ispartof | Brachytherapy, 2016, Vol.15 (1), p.57-64 |
| issn | 1538-4721 1873-1449 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1762026353 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Brachytherapy Brachytherapy - methods Computer Simulation Dose-volume histograms Female Hematology, Oncology and Palliative Medicine Humans Models, Theoretical Organs at Risk Radiology Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Radiotherapy, Image-Guided - methods Simulation analysis Tumor Burden Uterine cervical cancer Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy |
| title | Simulation analysis of optimized brachytherapy for uterine cervical cancer: Can we select the best brachytherapy modality depending on tumor size? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T20%3A25%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Simulation%20analysis%20of%20optimized%20brachytherapy%20for%20uterine%20cervical%20cancer:%20Can%20we%20select%20the%20best%20brachytherapy%20modality%20depending%20on%20tumor%20size?&rft.jtitle=Brachytherapy&rft.au=Yoshida,%20Ken&rft.date=2016&rft.volume=15&rft.issue=1&rft.spage=57&rft.epage=64&rft.pages=57-64&rft.issn=1538-4721&rft.eissn=1873-1449&rft_id=info:doi/10.1016/j.brachy.2015.10.002&rft_dat=%3Cproquest_cross%3E1762026353%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1762026353&rft_id=info:pmid/26612700&rft_els_id=1_s2_0_S1538472115005668&rfr_iscdi=true |