Allergic sensitization modifies the pulmonary expression of 5-hydroxytryptamine receptors in guinea pigs

Highlights • There is mounting evidence that 5-hydroxytryptamine (5-HT) plays a role in asthma. • Major 5-HT receptor subtypes are constitutively expressed in the guinea pig lung. • Allergic sensitization modifies the expression of 5-HT2A , 5-HT4 and 5-HT7 receptors. • The role of 5-HT in the pathog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Respiratory physiology & neurobiology 2016-03, Vol.223, p.9-15
Hauptverfasser:	Córdoba-Rodríguez, Guadalupe, Vargas, Mario H, Ruiz, Víctor, Carbajal, Verónica, Campos-Bedolla, Patricia, Mercadillo-Herrera, Paulina, Arreola-Ramírez, José Luis, Segura-Medina, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptors Allergic sensitization Animals Asthma - metabolism Asthma model Disease Models, Animal Guinea pig Guinea Pigs Hypersensitivity - metabolism Immunization Male Medical Education Pulmonary/Respiratory Receptor, Serotonin, 5-HT2A - metabolism Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT4 - metabolism Serotonin receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • There is mounting evidence that 5-hydroxytryptamine (5-HT) plays a role in asthma. • Major 5-HT receptor subtypes are constitutively expressed in the guinea pig lung. • Allergic sensitization modifies the expression of 5-HT2A , 5-HT4 and 5-HT7 receptors. • The role of 5-HT in the pathogenesis of asthma might lead to novel promising therapeutic approaches in the treatment of allergic airway diseases.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2015.11.018