Dermoscopy, reflectance confocal microscopy and histopathology of a melanoma in situ from an individual homozygous for GSTP1105Val/MC1R92Met

Glutathione S‐transferase 1 is an enzyme involved in the detoxification of reactive oxygen species, and the rs1695*Val polymorphism has been proposed as a melanoma‐associated variant with significant effect. We report a case of malignant melanoma in an individual homozygous for the rs1695*Val varian...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Australasian journal of dermatology 2016-02, Vol.57 (1), p.64-67
Hauptverfasser:	Banan, Parastoo, Lee, Katie J, McClenahan, Phil, Jagirdar, Kasturee, Sturm, Richard A, Soyer, H Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Case reports Confocal microscopy Dermoscopy Detoxification Glutathione S-Transferase pi - genetics Glutathione transferase GSTP1 Homozygote Humans Male Melanoma Melanoma - diagnostic imaging Melanoma - genetics Melanoma - pathology Microscopy, Confocal Neoplasms, Second Primary - diagnostic imaging Neoplasms, Second Primary - genetics Neoplasms, Second Primary - pathology RCM Reactive oxygen species regressive melanoma in situ Skin cancer skin microbiopsy Skin Neoplasms - diagnostic imaging Skin Neoplasms - genetics Skin Neoplasms - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Glutathione S‐transferase 1 is an enzyme involved in the detoxification of reactive oxygen species, and the rs1695Val polymorphism has been proposed as a melanoma‐associated variant with significant effect. We report a case of malignant melanoma in an individual homozygous for the rs1695Val variant and discuss the non‐invasive and histopathological tools used in diagnosis.
ISSN:	0004-8380 1440-0960
DOI:	10.1111/ajd.12250