Outcomes of Repeat Keratoplasty for Failed Therapeutic Keratoplasty

Purpose To analyze clinical outcomes of repeat optical penetrating (PK) or endothelial keratoplasty (EK) after failed therapeutic keratoplasty (TPK). Design Retrospective consecutive, comparative, interventional case series. Methods setting : LV Prasad Eye Institute, Hyderabad, India. study population : Patients aged >18 years who underwent a repeat PK or EK following a failed TPK with a follow-up of at least 1 year were included. Patients with culture-negative ulcers, viral etiology, coexistent ocular surface disease, and multiple grafts were excluded from the study. intervention : PK or EK for failed TPK. main outcome measure : Corrected distance visual acuity at 1 year follow-up. secondary outcome measure : Graft clarity. Results One hundred twelve eyes (67 PK, 45 EK) were included in the study. The PK group had a significantly higher number of cases with high-risk features prior to regraft. Improvement in visual acuity in each of the types of grafts was statistically significant ( P