Centrosome amplification and clonal evolution in multiple myeloma: Short review

Centrosome amplification and clonal evolution in multiple myeloma: Short review

Highlights • Existence of MM subclones with centrosome amplification. • Evolutionary behavior within intra-clonal heterogeneity. • Potential impact on the disease progression and MM treatment.

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Veröffentlicht in:Critical reviews in oncology/hematology 2016-02, Vol.98, p.116-121
Hauptverfasser: Kryukova, Elena, Kryukov, Fedor, Hajek, Roman
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis - physiology
Carcinogenesis - pathology
Cell Proliferation
Centrosome - pathology
Centrosome amplification
Clonal diversification
Clonal Evolution - physiology
Clone Cells
Disease Progression
Hematology, Oncology and Palliative Medicine
Humans
Multiple myeloma
Multiple Myeloma - genetics
Multiple Myeloma - pathology
Proliferation
Stress, Physiological - physiology
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Beschreibung
Zusammenfassung:Highlights • Existence of MM subclones with centrosome amplification. • Evolutionary behavior within intra-clonal heterogeneity. • Potential impact on the disease progression and MM treatment.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.10.019