Diverse autonomic regulation of pupillary function and the cardiovascular system during alcohol withdrawal

Highlights • Reduced sympathetic and vagal modulation during acute AWS at both pupils. • Cardiovascular parameters showed reduced vagal and mixed sympathetic modulation. • Most cardiac and pupillary parameters changed significantly after 24 h. • Pupillary parameters correlated in healthy controls wi...

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Veröffentlicht in:	Drug and alcohol dependence 2016-02, Vol.159, p.142-151
Hauptverfasser:	Jochum, Thomas, Hoyme, Johannes, Schulz, Steffen, Weißenfels, Markus, Voss, Andreas, Bär, Karl-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol dependence Autonomic Nervous System - drug effects Autonomic Nervous System - physiopathology Baroreflex - physiology Blood Pressure - physiology Cardiac mortality Cardiovascular System - drug effects Cardiovascular System - physiopathology Chlormethiazole - therapeutic use Heart Rate - physiology Heart rate variability Humans Locus coeruleus Male Middle Aged Psychiatry Pupil Reflex, Pupillary - physiology Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - physiopathology Vagal function Withdrawal
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Beschreibung
Zusammenfassung:	Highlights • Reduced sympathetic and vagal modulation during acute AWS at both pupils. • Cardiovascular parameters showed reduced vagal and mixed sympathetic modulation. • Most cardiac and pupillary parameters changed significantly after 24 h. • Pupillary parameters correlated in healthy controls with cardiac autonomic function. • Pupil findings are likely to show summarized effects of various brain regions.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2015.12.030