The short-term impact of each primary dose of pneumococcal conjugate vaccine on nasopharyngeal carriage: Systematic review and meta-analyses of randomised controlled trials

Highlights • We identified 16 eligible randomised controlled trials (14,776 participants). • We report meta-analyses of carriage after each dose of pneumococcal vaccine. • We found no significant short-term reduction in pneumococcal or NTHi carriage. • Vaccine type pneumococci declined after each do...

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Veröffentlicht in:	Vaccine 2016-02, Vol.34 (6), p.703-713
Hauptverfasser:	Nicholls, Thomas Rodger, Leach, Amanda Jane, Morris, Peter Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Carrier State - epidemiology Carrier State - microbiology Ear diseases Humans Infant Infants Nasopharyngeal carriage Nasopharynx - microbiology Native peoples Non-typeable haemophilus influenzae Otitis media Pneumococcal conjugate vaccine Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumonia Randomized Controlled Trials as Topic Short term Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Studies Toxins Vaccines Vaccines, Conjugate - administration & dosage
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Zusammenfassung:	Highlights • We identified 16 eligible randomised controlled trials (14,776 participants). • We report meta-analyses of carriage after each dose of pneumococcal vaccine. • We found no significant short-term reduction in pneumococcal or NTHi carriage. • Vaccine type pneumococci declined after each dose, significantly after 3 doses. • Current vaccines and schedules do not prevent early carriage of OM pathogens.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.12.048