The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation

The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation

Highlights • UVB irradiation causes stronger redox imbalance than UVA in keratinocytes and fibroblasts. • UV irradiation enhances lipid peroxidation, particularly at the level of 4-HNE and 4-HHE. • UV radiation decreases AEA and 2-AG level as well as their receptor activation. • Nrf2 activation foll...

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Veröffentlicht in:Journal of dermatological science 2016-02, Vol.81 (2), p.107-117
Hauptverfasser: Gęgotek, Agnieszka, Biernacki, Michał, Ambrożewicz, Ewa, Surażyński, Arkadiusz, Wroński, Adam, Skrzydlewska, Elżbieta
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants - metabolism
Apoptosis Regulatory Proteins - metabolism
Cell Communication - radiation effects
Cell Line
Dermatology
Endocannabinoids - metabolism
Fibroblasts
Fibroblasts - metabolism
Fibroblasts - radiation effects
Humans
Keratinocytes
Keratinocytes - metabolism
Keratinocytes - radiation effects
Lipid Peroxidation - radiation effects
NF-E2-Related Factor 2 - metabolism
NF-kappa B - metabolism
Nrf2
Nuclear Respiratory Factor 1 - metabolism
Oxidation-Reduction
Oxidative Stress - radiation effects
ROS
Signal Transduction - radiation effects
Superoxides - metabolism
Ultraviolet Rays
UV radiation
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Zusammenfassung:Highlights • UVB irradiation causes stronger redox imbalance than UVA in keratinocytes and fibroblasts. • UV irradiation enhances lipid peroxidation, particularly at the level of 4-HNE and 4-HHE. • UV radiation decreases AEA and 2-AG level as well as their receptor activation. • Nrf2 activation following UV irradiation varies depending on the skin cell type. • A potential relationship between UV-induced oxidative stress and the endocannabinoid system is suggested.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2015.11.005