A PPAR-gamma agonist attenuates pulmonary injury induced by irradiation in a murine model

Highlights • Radiotherapy leads to side effects because it affects normal tissues near the target. • Thoracic radiotherapy can cause radiation pneumonitis and pulmonary fibrosis. • Rosiglitazone has anti-inflammatory, antifibrotic and antineoplastic properties. • Rosiglitazone reduced signs of radia...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-12, Vol.90 (3), p.405-409
Hauptverfasser:	Mangoni, Monica, Sottili, Mariangela, Gerini, Chiara, Bonomo, Pierluigi, Bottoncetti, Anna, Castiglione, Francesca, Franzese, Ciro, Cassani, Sara, Greto, Daniela, Masoni, Tatiana, Meattini, Icro, Pallotta, Stefania, Passeri, Alessandro, Pupi, Alberto, Vanzi, Eleonora, Biti, Giampaolo, Livi, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Survival - radiation effects Disease Models, Animal Hematology, Oncology and Palliative Medicine Humans Lung Injury - diagnostic imaging Lung Injury - drug therapy Lung Injury - metabolism Lung Injury - pathology Mice PPAR gamma - agonists PPARgamma agonists Pulmonary/Respiratory Radiation Injuries, Experimental Radiation, Ionizing Radiation-induced lung toxicity Radiation-Protective Agents - pharmacology Radioprotection Radiotherapy Radiotherapy - adverse effects Thiazolidinediones - pharmacology Tomography, X-Ray Computed Xenograft Model Antitumor Assays
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Zusammenfassung:	Highlights • Radiotherapy leads to side effects because it affects normal tissues near the target. • Thoracic radiotherapy can cause radiation pneumonitis and pulmonary fibrosis. • Rosiglitazone has anti-inflammatory, antifibrotic and antineoplastic properties. • Rosiglitazone reduced signs of radiation-induced lung toxicity in a mouse model. • Rosiglitazone could be proposed as a radioprotective agent in thorax irradiation.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2015.11.005