Chiral Analysis Using Broadband Rotational Spectroscopy

broadband microwave spectroscopy is a proven tool to precisely determine molecular properties of gas-phase molecules. Recent developments make it applicable to investigate chiral molecules. Enantiomers can be differentiated, and the enantiomeric excess and, indirectly, the absolute configuration can...

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Veröffentlicht in:The journal of physical chemistry letters 2016-01, Vol.7 (2), p.341-350
Hauptverfasser: Shubert, V. Alvin, Schmitz, David, Pérez, Cristóbal, Medcraft, Chris, Krin, Anna, Domingos, Sérgio R, Patterson, David, Schnell, Melanie
Format: Artikel
Sprache:eng
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Zusammenfassung:broadband microwave spectroscopy is a proven tool to precisely determine molecular properties of gas-phase molecules. Recent developments make it applicable to investigate chiral molecules. Enantiomers can be differentiated, and the enantiomeric excess and, indirectly, the absolute configuration can be determined in a molecule-selective manner. The resonant character and high resolution of rotational spectroscopy provide a unique mixture compatibility. Future directions, such as extending the technique to chemical analysis, are discussed.
ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.5b02443