Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study

Highlights • The full ECT course is monitored in detail using four repeated measures of regional functional connectivity. • Our data support that a sequential limbic-prefrontal interaction is needed to bring about clinical recovery. • Our results are also relevant due to the finding of potential ear...

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Veröffentlicht in:	Brain stimulation 2016-01, Vol.9 (1), p.65-71
Hauptverfasser:	Cano, Marta, Cardoner, Narcís, Urretavizcaya, Mikel, Martínez-Zalacaín, Ignacio, Goldberg, Ximena, Via, Esther, Contreras-Rodríguez, Oren, Camprodon, Joan, de Arriba-Arnau, Aida, Hernández-Ribas, Rosa, Pujol, Jesús, Soriano-Mas, Carles, Menchón, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Depressive Disorder, Treatment-Resistant - physiopathology Depressive Disorder, Treatment-Resistant - therapy Electroconvulsive Therapy Female Humans Intralimbic modulation Limbic System - physiopathology Limbic–prefrontal modulation Male Middle Aged Neurology Prefrontal Cortex - physiopathology Treatment early biomarkers Treatment-resistant depression
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Zusammenfassung:	Highlights • The full ECT course is monitored in detail using four repeated measures of regional functional connectivity. • Our data support that a sequential limbic-prefrontal interaction is needed to bring about clinical recovery. • Our results are also relevant due to the finding of potential early biomarkers of treatment response.
ISSN:	1935-861X 1876-4754
DOI:	10.1016/j.brs.2015.08.016