Role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia

Role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia

To explore the role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia.
 Experiment were divided into a control group and a hypoxia group (n=20). After 5 weeks of hypoxia treatment, the expression of NF-κB p65 and p38 MAPK in lung tissues of rats were detected by...

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Veröffentlicht in:Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2015-12, Vol.40 (12), p.1313-1319
Hauptverfasser: Ge, Liqiao, Ming, Ting, Hou, Jin, Yan, Jing, Wang, Qiang, Qiao, Feng
Format: Artikel
Sprache:chi
Schlagworte:
Animals
Blotting, Western
Hypoxia - physiopathology
Lung - metabolism
Lung - pathology
Lung Injury - metabolism
Lung Injury - physiopathology
p38 Mitogen-Activated Protein Kinases - metabolism
Rats
Transcription Factor RelA - metabolism
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Zusammenfassung:To explore the role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia.
 Experiment were divided into a control group and a hypoxia group (n=20). After 5 weeks of hypoxia treatment, the expression of NF-κB p65 and p38 MAPK in lung tissues of rats were detected by optical microscope and immunohistochemical techniques and Western blot.
 Pathological examination showed pulmonary interval thickness was (0.45 ± 0.12) μm and (2.15 ± 0.49) μm in the control and hypoxia group, respectively (P
ISSN:1672-7347
DOI:10.11817/j.issn.1672-7347.2015.12.005