In vitro time–kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates

In vitro time–kill curves study of three antituberculous combinations against Mycobacterium tuberculosis clinical isolates

Highlights • The studied combinations were equally active against multidrug-resistant and -susceptible Mycobacterium tuberculosis isolates. • The combinations studied had an additive effect against M. tuberculosis isolates. • Time–kill methods are a good first step to test new drug regimens. • Time–...

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Veröffentlicht in:International journal of antimicrobial agents 2016-01, Vol.47 (1), p.97-100
Hauptverfasser: López-Gavín, Alexandre, Tudó, Griselda, Rey-Jurado, Emma, Vergara, Andrea, Hurtado, Juan Carlos, Gonzalez-Martín, Julian
Format: Artikel
Sprache:eng
Schlagworte:
Antitubercular Agents - pharmacology
Antituberculous drugs
Combinations
Drug Combinations
Drug Synergism
Humans
Infectious Disease
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Time–kill
Tuberculosis
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Zusammenfassung:Highlights • The studied combinations were equally active against multidrug-resistant and -susceptible Mycobacterium tuberculosis isolates. • The combinations studied had an additive effect against M. tuberculosis isolates. • Time–kill methods are a good first step to test new drug regimens. • Time–kill methods provide useful information about drug activity below the MIC.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.10.016