Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease

Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease

Background and Aims We previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking‐related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD). Methods and Results Plasma miRNAs profiling...

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Veröffentlicht in:The clinical respiratory journal 2016-01, Vol.10 (1), p.104-111
Hauptverfasser: Wang, Maoyun, Huang, Yuchuan, Liang, Zong'an, Liu, Dan, Lu, Yanrong, Dai, Ya, Feng, Guanglin, Wang, Changguo
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomarkers
Biomarkers - blood
Chronic obstructive pulmonary disease
COPD
Early Diagnosis
Female
Humans
Male
MicroRNAs - blood
Middle Aged
Plasma
plasma miRNAs
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - genetics
smoking
Smoking - adverse effects
Smoking - blood
Smoking - genetics
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Zusammenfassung:Background and Aims We previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking‐related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD). Methods and Results Plasma miRNAs profiling was performed in COPD patients, asthma patients, and matched healthy controls. There was a >2‐fold changes for all signature miRNAs between the COPD and control samples, with P values of
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12194