Self-Powered Photoelectrochemical Biosensor Based on CdS/RGO/ZnO Nanowire Array Heterostructure

A CdS/reduced graphene oxide (RGO)/ZnO nanowire array (NWAs) heterostructure is designed, which exhibits enhanced photoelectrochemical (PEC) activity compared to pure ZnO, RGO/ZnO, and CdS/ZnO. The enhancement can be attributed to the synergistic effect of the high electron mobility of ordered 1D ZnO NWAs, extended visible‐light absorption of CdS nanocrystals, and the formed type II band alignment between them. Moreover, the incorporation of RGO further promotes the charge carrier separation and transfer process due to its excellent charge collection and shuttling characteristics. Subsequently, the CdS/RGO/ZnO heterostructure is successfully utilized for the PEC bioanalysis of glutathione at 0 V (vs Ag/AgCl). The self‐powered device demonstrates satisfactory sensing performance with rapid response, a wide detection range from 0.05 mm to 1 mm, an acceptable detection limit of 10 μm, as well as certain selectivity, reproducibility, and stability. Therefore, the CdS/RGO/ZnO heterostructure has opened up a promising channel for the development of PEC biosensors. A CdS/RGO/ZnO nanoheterostructure is fabricated and then applied in the photoelectrochemical biosensing of glutathione. The biosensor is a self‐powered device with fast response, certain selectivity, reproducibility, and stability. The linear detection range of the device is from 0.05 mm to 1 mm and the detection limit is 10 μm.