ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

Reactome is a manually curated pathway annotation database for unveiling high-order biological pathways from high-throughput data. ReactomePA is an R/Bioconductor package providing enrichment analyses, including hypergeometric test and gene set enrichment analyses. A functional analysis can be applied to the genomic coordination obtained from a sequencing experiment to analyze the functional significance of genomic loci including cis -regulatory elements and non-coding regions. Comparison among different experiments is also supported. Moreover, ReactomePA provides several visualization functions to produce highly customizable, publication-quality figures. The source code and documents of ReactomePA are freely available through Bioconductor ( http://www.bioconductor.org/packages/ReactomePA ). ReactomePA is an R package providing functional analyses at the gene and sequence levels, with several visualization functions provided.