Atazanavir-loaded Eudragit RL 100 nanoparticles to improve oral bioavailability: optimization and in vitro/in vivo appraisal

Atazanavir (ATV) is a HIV protease inhibitor. Due to its intense lipophilicity, the oral delivery of ATV encounters several problems such as poor aqueous solubility, pH-dependent dissolution, rapid first-pass metabolism in liver by CYP3A5, which result in low bioavailability. To overcome afore menti...

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Veröffentlicht in:	Drug delivery 2016-02, Vol.23 (2), p.532-539
Hauptverfasser:	Singh, Gurinder, Pai, Roopa S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Administration, Oral Animals Atazanavir Sulfate - administration & dosage Atazanavir Sulfate - chemistry Atazanavir Sulfate - pharmacokinetics Bioavailability Biological Availability central composite design Delayed-Action Preparations Drug Carriers Drug Compounding HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacokinetics in situ single pass perfusion studies in vitro/in vivo correlation Intestinal Absorption Linear Models Male Microscopy, Electron, Transmission Models, Biological Nanoparticles Nanotechnology Nonlinear Dynamics Particle Size Permeability Peyer's Patches - metabolism pharmacokinetic study Rats, Wistar Solubility Surface Properties Technology, Pharmaceutical - methods
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