Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease
Highlights • Immune gene dysregulation in AD brains is linked to Aβ and tau pathology. • Immune gene dysregulation is consistently observed in AD blood as well. • Studies on isolated brain cells can provide clearer picture on immune dysregulation. • TREM2 is a unique gene with firm support from gene...
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| Veröffentlicht in: | Current opinion in pharmacology 2016-02, Vol.26, p.47-53 |
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| container_title | Current opinion in pharmacology |
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| creator | Song, Fuhai Qian, Ying Peng, Xing Han, Guangchun Wang, Jiajia Bai, Zhouxian Crack, Peter J Lei, Hongxing |
| description | Highlights • Immune gene dysregulation in AD brains is linked to Aβ and tau pathology. • Immune gene dysregulation is consistently observed in AD blood as well. • Studies on isolated brain cells can provide clearer picture on immune dysregulation. • TREM2 is a unique gene with firm support from genetic and transcriptomic studies. |
| doi_str_mv | 10.1016/j.coph.2015.09.015 |
| format | Article |
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| ispartof | Current opinion in pharmacology, 2016-02, Vol.26, p.47-53 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Alzheimer Disease - genetics Alzheimer Disease - immunology Animals Astrocytes - immunology Humans Immunity, Innate - genetics Internal Medicine Medical Education Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Microglia - immunology Receptors, Immunologic - genetics Receptors, Immunologic - immunology Transcriptome |
| title | Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease |
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