Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease

Highlights • Immune gene dysregulation in AD brains is linked to Aβ and tau pathology. • Immune gene dysregulation is consistently observed in AD blood as well. • Studies on isolated brain cells can provide clearer picture on immune dysregulation. • TREM2 is a unique gene with firm support from gene...

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Veröffentlicht in:	Current opinion in pharmacology 2016-02, Vol.26, p.47-53
Hauptverfasser:	Song, Fuhai, Qian, Ying, Peng, Xing, Han, Guangchun, Wang, Jiajia, Bai, Zhouxian, Crack, Peter J, Lei, Hongxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - immunology Animals Astrocytes - immunology Humans Immunity, Innate - genetics Internal Medicine Medical Education Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Microglia - immunology Receptors, Immunologic - genetics Receptors, Immunologic - immunology Transcriptome
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Zusammenfassung:	Highlights • Immune gene dysregulation in AD brains is linked to Aβ and tau pathology. • Immune gene dysregulation is consistently observed in AD blood as well. • Studies on isolated brain cells can provide clearer picture on immune dysregulation. • TREM2 is a unique gene with firm support from genetic and transcriptomic studies.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2015.09.015