Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia

Highlights • Prognostic impact of MRD after induction therapy by flow cytometry in 306 AML patients. • Allogeneic transplantation is better than autologous in patients with MRD > 0.1%. • MRD has special interest in the intermediate cytogenetic group. • Scoring system based on MRD and cytogenetics...

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Veröffentlicht in:	Leukemia research 2016-01, Vol.40, p.1-9
Hauptverfasser:	Vidriales, María-Belén, Pérez-López, Estefanía, Pegenaute, Carlota, Castellanos, Marta, Pérez, José-Juan, Chandía, Mauricio, Díaz-Mediavilla, Joaquín, Rayón, Consuelo, de las Heras, Natalia, Fernández-Abellán, Pascual, Cabezudo, Miguel, de Coca, Alfonso García, Alonso, Jose Mª, Olivier, Carmen, Hernández-Rivas, Jesús Mª, Montesinos, Pau, Fernández, Rosa, García- Suárez, Julio, García, Magdalena, Sayas, María-José, Paiva, Bruno, González, Marcos, Orfao, Alberto, San Miguel, Jesús F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukaemia Aged Chromosome Aberrations Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Middle Aged Minimal residual disease Neoplasm, Residual Prognosis
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Zusammenfassung:	Highlights • Prognostic impact of MRD after induction therapy by flow cytometry in 306 AML patients. • Allogeneic transplantation is better than autologous in patients with MRD > 0.1%. • MRD has special interest in the intermediate cytogenetic group. • Scoring system based on MRD and cytogenetics for the prognostic stratification.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.10.002