Can Insulin Production Suppress β Cell Growth?
While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell prolifer...
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| Veröffentlicht in: | Cell metabolism 2016-01, Vol.23 (1), p.4-5 |
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| creator | De Vas, Matias Ferrer, Jorge |
| description | While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation. |
| doi_str_mv | 10.1016/j.cmet.2015.12.016 |
| format | Article |
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While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2015.12.016</identifier><identifier>PMID: 26771111</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cell Cycle ; Cell Proliferation - drug effects ; Insulin - pharmacology ; Insulin-Like Growth Factor I - metabolism ; Insulin-Secreting Cells - metabolism</subject><ispartof>Cell metabolism, 2016-01, Vol.23 (1), p.4-5</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-8926998c124efac7c6a7d71ae7dd60ad89ec9e7c57f3f35737bf8713e4aac6813</citedby><cites>FETCH-LOGICAL-c400t-8926998c124efac7c6a7d71ae7dd60ad89ec9e7c57f3f35737bf8713e4aac6813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550413115006312$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26771111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Vas, Matias</creatorcontrib><creatorcontrib>Ferrer, Jorge</creatorcontrib><title>Can Insulin Production Suppress β Cell Growth?</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.</description><subject>Cell Cycle</subject><subject>Cell Proliferation - drug effects</subject><subject>Insulin - pharmacology</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-Secreting Cells - metabolism</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KxDAQhYMo7rr6Al5IL71pNz9t0oIgUnRdEBTU65BNppilfyat4mv5ID6TWXf10rmZ4fDNYeYgdEpwQjDh83WiGxgSikmWEJoEaQ9NScFoLFKK98OcZThOCSMTdOT9GmPGWcEO0YRyIUioKZqXqo2WrR9r20YPrjOjHmzXRo9j3zvwPvr6jEqo62jhuvfh5fIYHVSq9nCy6zP0fHP9VN7Gd_eLZXl1F-sU4yHOC8qLIteEplApLTRXwgiiQBjDsTJ5AboAoTNRsYplgolVlQvCIFVK85ywGTrf-vauex3BD7KxXodDVAvd6CURHOc5Fz8o3aLadd47qGTvbKPchyRYboKSa7kJSm6CkoTKIIWls53_uGrA_K38JhOAiy0A4cs3C056baHVYKwDPUjT2f_8vwHUSHj1</recordid><startdate>20160112</startdate><enddate>20160112</enddate><creator>De Vas, Matias</creator><creator>Ferrer, Jorge</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160112</creationdate><title>Can Insulin Production Suppress β Cell Growth?</title><author>De Vas, Matias ; Ferrer, Jorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-8926998c124efac7c6a7d71ae7dd60ad89ec9e7c57f3f35737bf8713e4aac6813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cell Cycle</topic><topic>Cell Proliferation - drug effects</topic><topic>Insulin - pharmacology</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-Secreting Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Vas, Matias</creatorcontrib><creatorcontrib>Ferrer, Jorge</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Vas, Matias</au><au>Ferrer, Jorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can Insulin Production Suppress β Cell Growth?</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2016-01-12</date><risdate>2016</risdate><volume>23</volume><issue>1</issue><spage>4</spage><epage>5</epage><pages>4-5</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26771111</pmid><doi>10.1016/j.cmet.2015.12.016</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell metabolism, 2016-01, Vol.23 (1), p.4-5 |
| issn | 1550-4131 1932-7420 |
| language | eng |
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| source | MEDLINE; Open Access: Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | Cell Cycle Cell Proliferation - drug effects Insulin - pharmacology Insulin-Like Growth Factor I - metabolism Insulin-Secreting Cells - metabolism |
| title | Can Insulin Production Suppress β Cell Growth? |
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