Can Insulin Production Suppress β Cell Growth?

While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell prolifer...

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Veröffentlicht in:	Cell metabolism 2016-01, Vol.23 (1), p.4-5
Hauptverfasser:	De Vas, Matias, Ferrer, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Cell Proliferation - drug effects Insulin - pharmacology Insulin-Like Growth Factor I - metabolism Insulin-Secreting Cells - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation. While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
ISSN:	1550-4131 1932-7420
DOI:	10.1016/j.cmet.2015.12.016