The role of vitamin D in post-thyroidectomy hypocalcemia: Still an enigma
Background There is conflicting evidence regarding the role of vitamin D deficiency in the development of post-thyroidectomy hypocalcemia. Recent reports show postoperative parathormone (PTH) is unreliable in predicting post-thyroidectomy hypocalcemia in vitamin D deficient patients. We conducted th...
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| Veröffentlicht in: | Surgery 2016-02, Vol.159 (2), p.532-538 |
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| creator | Cherian, Anish Jacob, MCh Ponraj, Sam, MS Gowri S, Mahasampath, MSc Ramakant, Pooja, MCh Paul, Thomas V., PhD Abraham, Deepak Thomas, PhD Paul, M.J., MS |
| description | Background There is conflicting evidence regarding the role of vitamin D deficiency in the development of post-thyroidectomy hypocalcemia. Recent reports show postoperative parathormone (PTH) is unreliable in predicting post-thyroidectomy hypocalcemia in vitamin D deficient patients. We conducted this study to analyze the role of vitamin D status in the development of post-thyroidectomy hypocalcemia and to evaluate its effect on the predictability of PTH as a marker for post-thyroidectomy hypocalcemia. Method A retrospective review of prospectively collected data of patients undergoing thyroidectomy between August 2007 to September 2013 ( n = 150) was performed. Results of preoperative calcium, albumin, vitamin D, PTH and postoperative calcium, albumin, and PTH were collated. Patients were divided into 2 groups based on their vitamin D status: group A, vitamin D ≥ 20 ng/mL and group B, vitamin D |
| doi_str_mv | 10.1016/j.surg.2015.08.014 |
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Recent reports show postoperative parathormone (PTH) is unreliable in predicting post-thyroidectomy hypocalcemia in vitamin D deficient patients. We conducted this study to analyze the role of vitamin D status in the development of post-thyroidectomy hypocalcemia and to evaluate its effect on the predictability of PTH as a marker for post-thyroidectomy hypocalcemia. Method A retrospective review of prospectively collected data of patients undergoing thyroidectomy between August 2007 to September 2013 ( n = 150) was performed. Results of preoperative calcium, albumin, vitamin D, PTH and postoperative calcium, albumin, and PTH were collated. Patients were divided into 2 groups based on their vitamin D status: group A, vitamin D ≥ 20 ng/mL and group B, vitamin D < 20 ng/mL. Results Vitamin D deficiency was present in 80 (53.3%) patients and post-thyroidectomy hypocalcemia developed in 67 (44.7%). The incidence of postoperative hypocalcemia was similar in both the groups (48.6% and 41.3%, respectively). Vitamin D status was not associated with the development of post-thyroidectomy hypocalcemia ( P = .23). Postoperative PTH of <8 pg/mL was strongly associated with the development of hypocalcemia in both the groups ( P = .0002 and .0045, respectively). The area under the receiver operator characteristic curve in group B (0.68) was less than in group A (0.76; P = .41). Conclusion The majority of patients were vitamin D deficient in this cohort, but this did not increase the risk of post-thyroidectomy hypocalcemia, nor did it interfere with the predictability of PTH as a marker of post-thyroidectomy hypocalcemia.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2015.08.014</identifier><identifier>PMID: 26365947</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Female ; Humans ; Hypocalcemia - diagnosis ; Hypocalcemia - epidemiology ; Hypocalcemia - etiology ; Incidence ; Male ; Middle Aged ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Surgery ; Thyroidectomy ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - diagnosis</subject><ispartof>Surgery, 2016-02, Vol.159 (2), p.532-538</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-78d545d2fc3ba649ed4cd4d90993f000342959b3531e472461419e90c9f7ad1e3</citedby><cites>FETCH-LOGICAL-c411t-78d545d2fc3ba649ed4cd4d90993f000342959b3531e472461419e90c9f7ad1e3</cites><orcidid>0000-0002-3649-8846</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039606015006376$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26365947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cherian, Anish Jacob, MCh</creatorcontrib><creatorcontrib>Ponraj, Sam, MS</creatorcontrib><creatorcontrib>Gowri S, Mahasampath, MSc</creatorcontrib><creatorcontrib>Ramakant, Pooja, MCh</creatorcontrib><creatorcontrib>Paul, Thomas V., PhD</creatorcontrib><creatorcontrib>Abraham, Deepak Thomas, PhD</creatorcontrib><creatorcontrib>Paul, M.J., MS</creatorcontrib><title>The role of vitamin D in post-thyroidectomy hypocalcemia: Still an enigma</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background There is conflicting evidence regarding the role of vitamin D deficiency in the development of post-thyroidectomy hypocalcemia. Recent reports show postoperative parathormone (PTH) is unreliable in predicting post-thyroidectomy hypocalcemia in vitamin D deficient patients. We conducted this study to analyze the role of vitamin D status in the development of post-thyroidectomy hypocalcemia and to evaluate its effect on the predictability of PTH as a marker for post-thyroidectomy hypocalcemia. Method A retrospective review of prospectively collected data of patients undergoing thyroidectomy between August 2007 to September 2013 ( n = 150) was performed. Results of preoperative calcium, albumin, vitamin D, PTH and postoperative calcium, albumin, and PTH were collated. Patients were divided into 2 groups based on their vitamin D status: group A, vitamin D ≥ 20 ng/mL and group B, vitamin D < 20 ng/mL. Results Vitamin D deficiency was present in 80 (53.3%) patients and post-thyroidectomy hypocalcemia developed in 67 (44.7%). The incidence of postoperative hypocalcemia was similar in both the groups (48.6% and 41.3%, respectively). Vitamin D status was not associated with the development of post-thyroidectomy hypocalcemia ( P = .23). Postoperative PTH of <8 pg/mL was strongly associated with the development of hypocalcemia in both the groups ( P = .0002 and .0045, respectively). The area under the receiver operator characteristic curve in group B (0.68) was less than in group A (0.76; P = .41). Conclusion The majority of patients were vitamin D deficient in this cohort, but this did not increase the risk of post-thyroidectomy hypocalcemia, nor did it interfere with the predictability of PTH as a marker of post-thyroidectomy hypocalcemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Hypocalcemia - diagnosis</subject><subject>Hypocalcemia - epidemiology</subject><subject>Hypocalcemia - etiology</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Thyroidectomy</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - diagnosis</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhS0EYpqBC7BAWbJJqIodJ0YIaTT8ayQWM6wtt12ZdpPEjZ2MlNtwFk6GWz2wYMGmavPeU9X3GHuOUCGgfLWv0hJvqxqwqaCrAMUDtsGG12XLJT5kGwCuSgkSztiTlPYAoAR2j9lZLblslGg37MvNjooYBipCX9z52Yx-Kt4VeRxCmst5t8bgHdk5jGuxWw_BmsHS6M3r4nr2w_Drp5kKmvztaJ6yR70ZEj273-fs24f3N5efyquvHz9fXlyVViDOZdu5RjSu7i3fGikUOWGdcAqU4n0-kYtaNWrLG44k2lpIFKhIgVV9axwSP2cvT7mHGH4slGY9-mRpGMxEYUkaWwldJ1CILK1PUhtDSpF6fYh-NHHVCPrIUO_1kaE-MtTQ6cwwm17c5y_bkdxfyx9oWfDmJKD85Z2nqJP1NFlyPmZS2gX___y3_9jt4CefwX6nldI-LHHK_DTqVGvQ18cWjyViAyB5K_lv8naXJg</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Cherian, Anish Jacob, MCh</creator><creator>Ponraj, Sam, MS</creator><creator>Gowri S, Mahasampath, MSc</creator><creator>Ramakant, Pooja, MCh</creator><creator>Paul, Thomas V., PhD</creator><creator>Abraham, Deepak Thomas, PhD</creator><creator>Paul, M.J., MS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3649-8846</orcidid></search><sort><creationdate>20160201</creationdate><title>The role of vitamin D in post-thyroidectomy hypocalcemia: Still an enigma</title><author>Cherian, Anish Jacob, MCh ; Ponraj, Sam, MS ; Gowri S, Mahasampath, MSc ; Ramakant, Pooja, MCh ; Paul, Thomas V., PhD ; Abraham, Deepak Thomas, PhD ; Paul, M.J., MS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-78d545d2fc3ba649ed4cd4d90993f000342959b3531e472461419e90c9f7ad1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Hypocalcemia - diagnosis</topic><topic>Hypocalcemia - epidemiology</topic><topic>Hypocalcemia - etiology</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Thyroidectomy</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cherian, Anish Jacob, MCh</creatorcontrib><creatorcontrib>Ponraj, Sam, MS</creatorcontrib><creatorcontrib>Gowri S, Mahasampath, MSc</creatorcontrib><creatorcontrib>Ramakant, Pooja, MCh</creatorcontrib><creatorcontrib>Paul, Thomas V., PhD</creatorcontrib><creatorcontrib>Abraham, Deepak Thomas, PhD</creatorcontrib><creatorcontrib>Paul, M.J., MS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cherian, Anish Jacob, MCh</au><au>Ponraj, Sam, MS</au><au>Gowri S, Mahasampath, MSc</au><au>Ramakant, Pooja, MCh</au><au>Paul, Thomas V., PhD</au><au>Abraham, Deepak Thomas, PhD</au><au>Paul, M.J., MS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of vitamin D in post-thyroidectomy hypocalcemia: Still an enigma</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>159</volume><issue>2</issue><spage>532</spage><epage>538</epage><pages>532-538</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>Background There is conflicting evidence regarding the role of vitamin D deficiency in the development of post-thyroidectomy hypocalcemia. Recent reports show postoperative parathormone (PTH) is unreliable in predicting post-thyroidectomy hypocalcemia in vitamin D deficient patients. We conducted this study to analyze the role of vitamin D status in the development of post-thyroidectomy hypocalcemia and to evaluate its effect on the predictability of PTH as a marker for post-thyroidectomy hypocalcemia. Method A retrospective review of prospectively collected data of patients undergoing thyroidectomy between August 2007 to September 2013 ( n = 150) was performed. Results of preoperative calcium, albumin, vitamin D, PTH and postoperative calcium, albumin, and PTH were collated. Patients were divided into 2 groups based on their vitamin D status: group A, vitamin D ≥ 20 ng/mL and group B, vitamin D < 20 ng/mL. Results Vitamin D deficiency was present in 80 (53.3%) patients and post-thyroidectomy hypocalcemia developed in 67 (44.7%). The incidence of postoperative hypocalcemia was similar in both the groups (48.6% and 41.3%, respectively). Vitamin D status was not associated with the development of post-thyroidectomy hypocalcemia ( P = .23). Postoperative PTH of <8 pg/mL was strongly associated with the development of hypocalcemia in both the groups ( P = .0002 and .0045, respectively). The area under the receiver operator characteristic curve in group B (0.68) was less than in group A (0.76; P = .41). Conclusion The majority of patients were vitamin D deficient in this cohort, but this did not increase the risk of post-thyroidectomy hypocalcemia, nor did it interfere with the predictability of PTH as a marker of post-thyroidectomy hypocalcemia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26365947</pmid><doi>10.1016/j.surg.2015.08.014</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3649-8846</orcidid></addata></record> |
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| subjects | Adult Aged Female Humans Hypocalcemia - diagnosis Hypocalcemia - epidemiology Hypocalcemia - etiology Incidence Male Middle Aged Postoperative Complications - diagnosis Postoperative Complications - epidemiology Postoperative Complications - etiology Prevalence Retrospective Studies Risk Factors Surgery Thyroidectomy Vitamin D Deficiency - complications Vitamin D Deficiency - diagnosis |
| title | The role of vitamin D in post-thyroidectomy hypocalcemia: Still an enigma |
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