Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients

Highlights • The high level of KIF23 expression was observed in majority of metastatic lung cancer tissue compared with normal lung control. • KIF23 is crucial for the growth and survival of lung cancer cells. • A high level of the KIF23 is strongly associated with poor survival in patients with lun...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-02, Vol.92, p.53-61
Hauptverfasser:	Kato, Tatsuya, Wada, Hironobu, Patel, Priya, Hu, Hsin-pei, Lee, Daiyoon, Ujiie, Hideki, Hirohashi, Kentaro, Nakajima, Takahiro, Sato, Masaaki, Kaji, Mitsuhito, Kaga, Kichizo, Matsui, Yoshiro, Tsao, Ming-Sound, Yasufuku, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cell Line, Tumor Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry KIF23 (MKLP1) Kinesin motor Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis Male Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Middle Aged Prognosis Prognostic factor Pulmonary/Respiratory Up-Regulation
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Zusammenfassung:	Highlights • The high level of KIF23 expression was observed in majority of metastatic lung cancer tissue compared with normal lung control. • KIF23 is crucial for the growth and survival of lung cancer cells. • A high level of the KIF23 is strongly associated with poor survival in patients with lung adenocarcinoma. • KIF23 can be valuable for developing new therapeutic targets for advanced lung cancers.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2015.11.018