Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery
A star polymer of poly[( R , S )-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di- O -methyl)-β-CD and...
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| Veröffentlicht in: | Nanoscale 2016-01, Vol.8 (3), p.1332-1337 |
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| container_title | Nanoscale |
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| creator | Zhu, Jing-ling Liu, Kerh Li Wen, Yuting Song, Xia Li, Jun |
| description | A star polymer of poly[(
R
,
S
)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-
O
-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin.
Star-shaped poly[(
R
,
S
)-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host-guest interaction with heptakis(2,6-di-
O
-methyl)-β-cyclodextrin. The nanovesicle is efficient for intracellular drug delivery. |
| doi_str_mv | 10.1039/c5nr06744h |
| format | Article |
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R
,
S
)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-
O
-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin.
Star-shaped poly[(
R
,
S
)-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host-guest interaction with heptakis(2,6-di-
O
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R
,
S
)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-
O
-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin.
Star-shaped poly[(
R
,
S
)-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host-guest interaction with heptakis(2,6-di-
O
-methyl)-β-cyclodextrin. The nanovesicle is efficient for intracellular drug delivery.</description><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - pharmacokinetics</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Architecture</subject><subject>Doxorubicin</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Drug Carriers - pharmacology</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Formations</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydroxybutyrates - chemistry</subject><subject>Hydroxybutyrates - pharmacokinetics</subject><subject>Hydroxybutyrates - pharmacology</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructure</subject><subject>Polyesters - chemistry</subject><subject>Polyesters - pharmacokinetics</subject><subject>Polyesters - pharmacology</subject><subject>Polyhydroxybutyrate</subject><subject>Stars</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7odevCs5itBupZNJJ0cZVkdYVlj03KST6p1Id3rMx8L-hf3VZnZ2x6NUQb1UPbxQvIS8Y_CZAdcXdhUiyE6I7Qty2oKAhvOufXnUUpyQs5R-A0jNJX9NTlopdT2yU_KwWVJubgumTH3IGI3NfglVu2LR0VR20czLhLZMJlIz77a-9uQtTXm_iHbrM9pcIlITHC3Bj0ucaTBhucPk7YR0vzCPtlVVKntrgsVIXSy31OHk7zDevyGvRjMlfPs0z8mvr5c_15vm6se37-svV40VoHKjoR0caoZKg0POlWpx6ECjtG07Oims0AMwxzQaDoPgStTSre2E5qNQ_Jx8PPju4vJn_3g_-2RxmkzApaSeKVCgJYjV_9FOglKsE6yinw6ojUtKEcd-F_1s4n3PoN_H1K9X1zePMW0q_OHJtwwzuiP6nEsF3h-AmOzx-i9n_hd9kJpJ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Zhu, Jing-ling</creator><creator>Liu, Kerh Li</creator><creator>Wen, Yuting</creator><creator>Song, Xia</creator><creator>Li, Jun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20160101</creationdate><title>Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery</title><author>Zhu, Jing-ling ; Liu, Kerh Li ; Wen, Yuting ; Song, Xia ; Li, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-902bde91e890de33882eb709e6c22fd64c49b01d19ea30b438484892c7493f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - pharmacokinetics</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Architecture</topic><topic>Doxorubicin</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Drug Carriers - pharmacology</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Formations</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydroxybutyrates - chemistry</topic><topic>Hydroxybutyrates - pharmacokinetics</topic><topic>Hydroxybutyrates - pharmacology</topic><topic>Nanoparticles - chemistry</topic><topic>Nanostructure</topic><topic>Polyesters - chemistry</topic><topic>Polyesters - pharmacokinetics</topic><topic>Polyesters - pharmacology</topic><topic>Polyhydroxybutyrate</topic><topic>Stars</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Jing-ling</creatorcontrib><creatorcontrib>Liu, Kerh Li</creatorcontrib><creatorcontrib>Wen, Yuting</creatorcontrib><creatorcontrib>Song, Xia</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Jing-ling</au><au>Liu, Kerh Li</au><au>Wen, Yuting</au><au>Song, Xia</au><au>Li, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>8</volume><issue>3</issue><spage>1332</spage><epage>1337</epage><pages>1332-1337</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>A star polymer of poly[(
R
,
S
)-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di-
O
-methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin.
Star-shaped poly[(
R
,
S
)-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host-guest interaction with heptakis(2,6-di-
O
-methyl)-β-cyclodextrin. The nanovesicle is efficient for intracellular drug delivery.</abstract><cop>England</cop><pmid>26692041</pmid><doi>10.1039/c5nr06744h</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| issn | 2040-3364 2040-3372 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - pharmacology Architecture Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Drug delivery systems Drugs Formations HeLa Cells Humans Hydroxybutyrates - chemistry Hydroxybutyrates - pharmacokinetics Hydroxybutyrates - pharmacology Nanoparticles - chemistry Nanostructure Polyesters - chemistry Polyesters - pharmacokinetics Polyesters - pharmacology Polyhydroxybutyrate Stars |
| title | Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery |
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