Host-guest interaction induced supramolecular amphiphilic star architecture and uniform nanovesicle formation for anticancer drug delivery

A star polymer of poly[( R , S )-3-hydroxybutyrate] (PHB) with adamantyl end-terminals extended from an α-cyclodextrin (α-CD) core is designed. It subsequently self-assembles to form controllable and uniform nanovesicles induced by host-guest interactions between heptakis(2,6-di- O -methyl)-β-CD and the adamantyl ends. The nanovesicles are suitable for loading and intracellular delivery of the anticancer drug doxorubicin. Star-shaped poly[( R , S )-3-hydroxybutyrate] with an α-cyclodextrin core and adamantyl end-terminals self-assembles into nanovesicle through host-guest interaction with heptakis(2,6-di- O -methyl)-β-cyclodextrin. The nanovesicle is efficient for intracellular drug delivery.