Left ventricular sphericity independently predicts appropriate implantable cardioverter-defibrillator therapy

Background Whether echocardiographic markers of remodeling are associated with ventricular tachyarrhythmias is unknown. Objective The purpose of this study was to determine whether a transthoracic echocardiographic (TTE) marker of spherical left ventricular (LV) remodeling is associated with appropr...

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Veröffentlicht in:	Heart rhythm 2016-02, Vol.13 (2), p.490-497
Hauptverfasser:	Levine, Yehoshua C., MD, Matos, Jason, MD, Rosenberg, Michael A., MD, Manning, Warren J., MD, Josephson, Mark E., MD, Buxton, Alfred E., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac Resynchronization Therapy - methods Cardiovascular Death, Sudden, Cardiac - etiology Death, Sudden, Cardiac - prevention & control Defibrillators, Implantable Diagnosis, Computer-Assisted Echocardiography - methods Female Follow-Up Studies Heart Ventricles - diagnostic imaging Humans Implantable cardioverter-defibrillator Left ventricular sphericity Male Middle Aged Predictive Value of Tests Prognosis Remodeling Risk Assessment - methods Risk Factors Risk stratification Tachycardia, Ventricular - complications Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - therapy Treatment Outcome Ventricular arrhythmia Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling
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Zusammenfassung:	Background Whether echocardiographic markers of remodeling are associated with ventricular tachyarrhythmias is unknown. Objective The purpose of this study was to determine whether a transthoracic echocardiographic (TTE) marker of spherical left ventricular (LV) remodeling is associated with appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with primary prevention ICDs. Methods From TTE images, we calculated sphericity index (SI), the ratio of biplane LV end-diastolic volume to the volume of a hypothetical sphere with a diameter of the LV end-diastolic length, and examined the relation between SI and therapy for ventricular tachyarrhythmias in 278 patients with primary prevention ICDs and in 50 controls without structural heart disease or ventricular arrhythmias. Results SI in normal healthy adult subjects and in subjects receiving ICDs was 0.44 ± 0.02 and 0.65 ± 0.04, respectively ( P
ISSN:	1547-5271 1556-3871
DOI:	10.1016/j.hrthm.2015.09.022