Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction

Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction

Aim Growth differentiation factor 15 (GDF15) is a cytokine highly expressed in states of inflammatory stress. We aimed to study the clinical correlates and prognostic significance of plasma GDF15 in heart failure with preserved ejection fraction (HFpEF) vs. reduced ejection fraction(HFrEF), compared...

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Veröffentlicht in:European journal of heart failure 2016-01, Vol.18 (1), p.81-88
Hauptverfasser: Chan, Michelle M.Y., Santhanakrishnan, Rajalakshmi, Chong, Jenny P.C., Chen, Zhaojin, Tai, Bee Choo, Liew, Oi Wah, Ng, Tze Pin, Ling, Lieng H., Sim, David, Leong, Kui Toh G., Yeo, Poh Shuan Daniel, Ong, Hean-Yee, Jaufeerally, Fazlur, Wong, Raymond Ching-Chiew, Chai, Ping, Low, Adrian F., Richards, Arthur M., Lam, Carolyn S.P.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomarkers - blood
Female
Growth differentiation factor 15
Growth Differentiation Factor 15 - blood
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - physiopathology
Heart failure with preserved ejection fraction
Humans
Inflammation - blood
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Natriuretic peptides
Patient Readmission - statistics & numerical data
Peptide Fragments - blood
Prognosis
Proportional Hazards Models
ROC Curve
Singapore - epidemiology
Stroke Volume
Survival Analysis
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Zusammenfassung:Aim Growth differentiation factor 15 (GDF15) is a cytokine highly expressed in states of inflammatory stress. We aimed to study the clinical correlates and prognostic significance of plasma GDF15 in heart failure with preserved ejection fraction (HFpEF) vs. reduced ejection fraction(HFrEF), compared with N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), an indicator of haemodynamic wall stress. Methods Plasma GDF15 and NT‐proBNP were prospectively measured in 916 consecutive patients with HFrEF (EF
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.431