Fatty liver disease, glucose tolerance and insulin resistance in obese adolescents

Summary Background/objectives Adult studies suggest that intra‐hepatic fat predicts 2‐h blood glucose levels and type 2 diabetes, and may have a role in the development of insulin resistance. Our study objective was to explore relationships between intra‐hepatic fat and (i) blood glucose levels and (ii) insulin resistance determined by homeostasis model assessment (HOMA) in a group of obese adolescents. Methods Subjects were 61 obese non‐diabetic male and female volunteers aged 12–18 years inclusive with a body mass index >95th percentile for age and 2‐h blood glucose