Two-photon sensitized hollow Gd2O3:Eu(3+) nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release

Two-photon sensitized hollow Gd2O3:Eu(3+) nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release

New two-photon sensitized multifunctional nanocomposites were designed for dual-mode imaging and real-time drug release monitoring by photoluminescence (PL) and magnetic resonance imaging (MRI). By drug loading based on coordination effect, PL signals of Eu(3+) and MRI signals of Gd(3+) can be stabi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (7), p.1447-1450
Hauptverfasser: Shen, Tingting, Zhang, Yu, Kirillov, Alexander M, Cai, Huijuan, Huang, Kun, Liu, Weisheng, Tang, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, Antineoplastic - administration & dosage
Doxorubicin - administration & dosage
Europium - chemistry
Gadolinium - chemistry
HeLa Cells
Humans
Magnetic Resonance Imaging
Microscopy, Electron, Transmission
Nanocomposites
Photons
Powder Diffraction
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Zusammenfassung:New two-photon sensitized multifunctional nanocomposites were designed for dual-mode imaging and real-time drug release monitoring by photoluminescence (PL) and magnetic resonance imaging (MRI). By drug loading based on coordination effect, PL signals of Eu(3+) and MRI signals of Gd(3+) can be stabilized and enhanced, respectively, which then display excellent linear decreases on drug release.
ISSN:1364-548X
DOI:10.1039/c5cc07609a