Look-back study on recipients of Parvovirus B19 (B19V) DNA-positive blood components

Background and Objectives To assess the relevance of Parvovirus B19 (B19V) DNA at low to intermediate concentrations in blood donors for the recipients of their blood components. Material and Methods We studied recipients of B19V DNA‐positive blood components [red blood cell concentrates (RBCs), poo...

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Veröffentlicht in:	Vox sanguinis 2015-11, Vol.109 (4), p.305-311
Hauptverfasser:	Juhl, D., Özdemir, M., Dreier, J., Görg, S., Hennig, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B19V Base Sequence Blood & organ donations Blood Component Transfusion Blood Donors Blood transfusions Deoxyribonucleic acid DNA DNA, Viral - blood Female Hematology Humans Male Middle Aged Molecular Sequence Data Parvoviridae Infections - blood Parvoviridae Infections - transmission Parvovirus B19 Parvovirus B19 infection Parvovirus B19, Human - genetics Parvovirus B19, Human - isolation & purification transfusion-transmitted infection
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Zusammenfassung:	Background and Objectives To assess the relevance of Parvovirus B19 (B19V) DNA at low to intermediate concentrations in blood donors for the recipients of their blood components. Material and Methods We studied recipients of B19V DNA‐positive blood components [red blood cell concentrates (RBCs), pooled platelet concentrates and fresh frozen plasma]. This included archived pretransfusion samples as well as follow‐up samples investigated by ELISA or NAT and genome sequence analysis. Results In 132 out of 424 recipients, we could detect no anti‐B19V IgG before transfusion. In 67 out of 132 sero‐negative recipients, a follow‐up sample was available. Sixty‐five of these received blood components from donors with
ISSN:	0042-9007 1423-0410
DOI:	10.1111/vox.12295