The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals
Background & Aims The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non‐overweight individuals with NAFLD. Methods A population‐based retrospective cohort study of 4629 participants who were enrolled in a...
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| Veröffentlicht in: | Liver international 2016-02, Vol.36 (2), p.275-283 |
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| creator | Fukuda, Takuya Hamaguchi, Masahide Kojima, Takao Hashimoto, Yoshitaka Ohbora, Akihiro Kato, Takahiro Nakamura, Naoto Fukui, Michiaki |
| description | Background & Aims
The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non‐overweight individuals with NAFLD.
Methods
A population‐based retrospective cohort study of 4629 participants who were enrolled in a health check‐up programme for more than 10 years. A standardized questionnaire and abdominal ultrasonography were used to diagnose NAFLD. A cut‐off point of BMI 23 kg/m2 was used to define overweight (≥23.0 kg/m2) or non‐overweight ( |
| doi_str_mv | 10.1111/liv.12912 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1760870266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760870266</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5132-bea1605650eac90063b1d6048b4e35707e55a85fe73c41c8b5fe5f9834eb1e73</originalsourceid><addsrcrecordid>eNp1kE1PxCAQhonR-H3wDxiOeqhCKdAedeNXsmqMG028EEqnLtqWtVB1_73o6t7kMpPhmSeTF6E9So5ofMeNfT-iaUHTFbRJM5knLGV0ddmnbANtef9CCC0KTtfRRiqoFJKSTdRPpoBtO9MmYFfjznWJboybusYaXOsQ5jjaoceV9aA9YNdh2xlbQRdwmM8Ap_FLlxDA4xaaxobBR-LH5OLiB9jnaYiTyr7batCN30FrdSyw-1u30eT8bDK6TMa3F1ejk3FiOGVpUoKmgnDBCWhTECJYSStBsrzMgHFJJHCuc16DZCajJi9jy-siZxmUNA630cFCO-vd2wA-qNZ6Ey_UHbjBq5gAySVJhYjo4QI1vfO-h1rNetvqfq4oUd8Jq5iB-kk4svu_2qFsoVqSf5FG4HgBfNgG5v-b1Pjq4U-ZLDasD_C53ND9qxKSSa4eby5UQZ7u5OP9qbpmX3-xlX8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1760870266</pqid></control><display><type>article</type><title>The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fukuda, Takuya ; Hamaguchi, Masahide ; Kojima, Takao ; Hashimoto, Yoshitaka ; Ohbora, Akihiro ; Kato, Takahiro ; Nakamura, Naoto ; Fukui, Michiaki</creator><creatorcontrib>Fukuda, Takuya ; Hamaguchi, Masahide ; Kojima, Takao ; Hashimoto, Yoshitaka ; Ohbora, Akihiro ; Kato, Takahiro ; Nakamura, Naoto ; Fukui, Michiaki</creatorcontrib><description>Background & Aims
The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non‐overweight individuals with NAFLD.
Methods
A population‐based retrospective cohort study of 4629 participants who were enrolled in a health check‐up programme for more than 10 years. A standardized questionnaire and abdominal ultrasonography were used to diagnose NAFLD. A cut‐off point of BMI 23 kg/m2 was used to define overweight (≥23.0 kg/m2) or non‐overweight (<23.0 kg/m2). The primary outcome was incident T2DM.
Results
Over a mean follow‐up of 12.8 years, 351 participants (7.6%) developed T2DM. The incidence rate of T2DM was 3.2% in the non‐overweight without NAFLD group, 14.4% in the non‐overweight with NAFLD group, 8.0% in the overweight without NAFLD group and 26.4% in the overweight with NAFLD group. The adjusted hazard ratios for incident T2DM compared with the non‐overweight without NAFLD group were as follows: 3.59 (95% CI: 2.14–5.76) in the non‐overweight with NAFLD group, 1.99 (95% CI: 1.47–2.69) in the overweight without NAFLD group and 6.77 (95% CI: 5.17–8.91) in the overweight with NAFLD group. The adjusted hazard ratio in the non‐overweight with NAFLD group was significantly higher than that in the overweight without NAFLD group or that in the non‐overweight without NAFLD group.
Conclusions
Non‐overweight individuals with NAFLD had a high risk of incident T2DM. Diagnosis of NAFLD is important in non‐overweight individuals, and therefore it might be necessary to follow their health conditions on a long‐term basis after detection of NAFLD.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.12912</identifier><identifier>PMID: 26176710</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Body Mass Index ; cohort study ; diabetes ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; epidemiology ; Female ; Humans ; Incidence ; Japan - epidemiology ; Liver - diagnostic imaging ; liver disease ; Male ; Middle Aged ; non-alcoholic fatty liver ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - epidemiology ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Ultrasonography</subject><ispartof>Liver international, 2016-02, Vol.36 (2), p.275-283</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5132-bea1605650eac90063b1d6048b4e35707e55a85fe73c41c8b5fe5f9834eb1e73</citedby><cites>FETCH-LOGICAL-c5132-bea1605650eac90063b1d6048b4e35707e55a85fe73c41c8b5fe5f9834eb1e73</cites><orcidid>0000-0002-8651-4445</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.12912$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.12912$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26176710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuda, Takuya</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Kojima, Takao</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Ohbora, Akihiro</creatorcontrib><creatorcontrib>Kato, Takahiro</creatorcontrib><creatorcontrib>Nakamura, Naoto</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><title>The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non‐overweight individuals with NAFLD.
Methods
A population‐based retrospective cohort study of 4629 participants who were enrolled in a health check‐up programme for more than 10 years. A standardized questionnaire and abdominal ultrasonography were used to diagnose NAFLD. A cut‐off point of BMI 23 kg/m2 was used to define overweight (≥23.0 kg/m2) or non‐overweight (<23.0 kg/m2). The primary outcome was incident T2DM.
Results
Over a mean follow‐up of 12.8 years, 351 participants (7.6%) developed T2DM. The incidence rate of T2DM was 3.2% in the non‐overweight without NAFLD group, 14.4% in the non‐overweight with NAFLD group, 8.0% in the overweight without NAFLD group and 26.4% in the overweight with NAFLD group. The adjusted hazard ratios for incident T2DM compared with the non‐overweight without NAFLD group were as follows: 3.59 (95% CI: 2.14–5.76) in the non‐overweight with NAFLD group, 1.99 (95% CI: 1.47–2.69) in the overweight without NAFLD group and 6.77 (95% CI: 5.17–8.91) in the overweight with NAFLD group. The adjusted hazard ratio in the non‐overweight with NAFLD group was significantly higher than that in the overweight without NAFLD group or that in the non‐overweight without NAFLD group.
Conclusions
Non‐overweight individuals with NAFLD had a high risk of incident T2DM. Diagnosis of NAFLD is important in non‐overweight individuals, and therefore it might be necessary to follow their health conditions on a long‐term basis after detection of NAFLD.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>cohort study</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Liver - diagnostic imaging</subject><subject>liver disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>non-alcoholic fatty liver</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - diagnosis</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PxCAQhonR-H3wDxiOeqhCKdAedeNXsmqMG028EEqnLtqWtVB1_73o6t7kMpPhmSeTF6E9So5ofMeNfT-iaUHTFbRJM5knLGV0ddmnbANtef9CCC0KTtfRRiqoFJKSTdRPpoBtO9MmYFfjznWJboybusYaXOsQ5jjaoceV9aA9YNdh2xlbQRdwmM8Ap_FLlxDA4xaaxobBR-LH5OLiB9jnaYiTyr7batCN30FrdSyw-1u30eT8bDK6TMa3F1ejk3FiOGVpUoKmgnDBCWhTECJYSStBsrzMgHFJJHCuc16DZCajJi9jy-siZxmUNA630cFCO-vd2wA-qNZ6Ey_UHbjBq5gAySVJhYjo4QI1vfO-h1rNetvqfq4oUd8Jq5iB-kk4svu_2qFsoVqSf5FG4HgBfNgG5v-b1Pjq4U-ZLDasD_C53ND9qxKSSa4eby5UQZ7u5OP9qbpmX3-xlX8</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Fukuda, Takuya</creator><creator>Hamaguchi, Masahide</creator><creator>Kojima, Takao</creator><creator>Hashimoto, Yoshitaka</creator><creator>Ohbora, Akihiro</creator><creator>Kato, Takahiro</creator><creator>Nakamura, Naoto</creator><creator>Fukui, Michiaki</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8651-4445</orcidid></search><sort><creationdate>201602</creationdate><title>The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals</title><author>Fukuda, Takuya ; Hamaguchi, Masahide ; Kojima, Takao ; Hashimoto, Yoshitaka ; Ohbora, Akihiro ; Kato, Takahiro ; Nakamura, Naoto ; Fukui, Michiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5132-bea1605650eac90063b1d6048b4e35707e55a85fe73c41c8b5fe5f9834eb1e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>cohort study</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Liver - diagnostic imaging</topic><topic>liver disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>non-alcoholic fatty liver</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Non-alcoholic Fatty Liver Disease - diagnosis</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuda, Takuya</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Kojima, Takao</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Ohbora, Akihiro</creatorcontrib><creatorcontrib>Kato, Takahiro</creatorcontrib><creatorcontrib>Nakamura, Naoto</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuda, Takuya</au><au>Hamaguchi, Masahide</au><au>Kojima, Takao</au><au>Hashimoto, Yoshitaka</au><au>Ohbora, Akihiro</au><au>Kato, Takahiro</au><au>Nakamura, Naoto</au><au>Fukui, Michiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2016-02</date><risdate>2016</risdate><volume>36</volume><issue>2</issue><spage>275</spage><epage>283</epage><pages>275-283</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
The aim of this study was to evaluate the impact of non‐alcoholic fatty liver disease (NAFLD) on incident type 2 diabetes mellitus (T2DM) in non‐overweight individuals with NAFLD.
Methods
A population‐based retrospective cohort study of 4629 participants who were enrolled in a health check‐up programme for more than 10 years. A standardized questionnaire and abdominal ultrasonography were used to diagnose NAFLD. A cut‐off point of BMI 23 kg/m2 was used to define overweight (≥23.0 kg/m2) or non‐overweight (<23.0 kg/m2). The primary outcome was incident T2DM.
Results
Over a mean follow‐up of 12.8 years, 351 participants (7.6%) developed T2DM. The incidence rate of T2DM was 3.2% in the non‐overweight without NAFLD group, 14.4% in the non‐overweight with NAFLD group, 8.0% in the overweight without NAFLD group and 26.4% in the overweight with NAFLD group. The adjusted hazard ratios for incident T2DM compared with the non‐overweight without NAFLD group were as follows: 3.59 (95% CI: 2.14–5.76) in the non‐overweight with NAFLD group, 1.99 (95% CI: 1.47–2.69) in the overweight without NAFLD group and 6.77 (95% CI: 5.17–8.91) in the overweight with NAFLD group. The adjusted hazard ratio in the non‐overweight with NAFLD group was significantly higher than that in the overweight without NAFLD group or that in the non‐overweight without NAFLD group.
Conclusions
Non‐overweight individuals with NAFLD had a high risk of incident T2DM. Diagnosis of NAFLD is important in non‐overweight individuals, and therefore it might be necessary to follow their health conditions on a long‐term basis after detection of NAFLD.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26176710</pmid><doi>10.1111/liv.12912</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8651-4445</orcidid></addata></record> |
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| ispartof | Liver international, 2016-02, Vol.36 (2), p.275-283 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Body Mass Index cohort study diabetes Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology epidemiology Female Humans Incidence Japan - epidemiology Liver - diagnostic imaging liver disease Male Middle Aged non-alcoholic fatty liver Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Proportional Hazards Models Retrospective Studies Risk Factors Ultrasonography |
| title | The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals |
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