Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherap...

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Veröffentlicht in:	Molecular biology reports 2016-02, Vol.43 (2), p.107-116
Hauptverfasser:	Mehdizadeh, Amir, Somi, Mohammad Hossein, Darabi, Masoud, Jabbarpour-Bonyadi, Mortaza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animals Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cellular biology Drug Resistance, Neoplasm - genetics Drug therapy Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Hepatology Histology Humans Kinases Life Sciences Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - pathology Mini Review Article Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Models, Molecular Morphology Protein Kinase Inhibitors - therapeutic use Signal Transduction Tumors
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Zusammenfassung:	Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-016-3943-9