Alterations of MET Gene Copy Number and Protein Expression in Primary Non–Small-Cell Lung Cancer and Corresponding Nodal Metastases

Micro-Abstract Alterations of the potential therapeutic target mesenchymal epithelial transition factor (MET) were assessed in 300 non–small-cell lung cancer specimens including 93 with nodal metastases using immunohistochemistry and fluorescent in situ hybridization. We found that MET alterations w...

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Veröffentlicht in:	Clinical lung cancer 2016-01, Vol.17 (1), p.30-38.e1
Hauptverfasser:	Tran, Thang N, Selinger, Christina I, Kohonen-Corish, Maija R.J, McCaughan, Brian, Kennedy, Catherine, O'Toole, Sandra A, Cooper, Wendy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Adult Aged Aged, 80 and over Biomarker Biomarkers, Tumor Carcinoma, Large Cell - genetics Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - secondary Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Case-Control Studies Female Fluorescent in situ hybridization Follow-Up Studies Gene Dosage Hematology, Oncology and Palliative Medicine Hepatocyte growth factor receptor Humans Immunoenzyme Techniques Immunohistochemistry In Situ Hybridization, Fluorescence Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis Male Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Prognosis Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Pulmonary/Respiratory Retrospective Studies Survival Rate Tissue Array Analysis
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Zusammenfassung:	Micro-Abstract Alterations of the potential therapeutic target mesenchymal epithelial transition factor (MET) were assessed in 300 non–small-cell lung cancer specimens including 93 with nodal metastases using immunohistochemistry and fluorescent in situ hybridization. We found that MET alterations were more frequently seen in metastases than primary tumors and were associated with better overall survival of patients.
ISSN:	1525-7304 1938-0690
DOI:	10.1016/j.cllc.2015.08.002