Association of matrix metalloproteinase-10 polymorphisms with susceptibility to pelvic organ prolapse

Aim The aim of this study was to explore the correlation between genetic mutations in matrix metalloproteinase‐10 (MMP‐10) and susceptibility to pelvic organ prolapse (POP). Material and Methods From September 2011 to December 2013, 263 subjects were recruited, including 91 patients with POP (case group) and 172 non‐POP patients (control group). Total MMP‐10 concentrations in serum were measured by enzyme‐linked immunosorbent assay. The genotyping of MMP‐10 was achieved by quantitative real‐time polymerase chain reaction. All data were analyzed with spss 18.0. Results We found that parity, menopause, history of total hysterectomy, and family history of POP were all significantly higher in the POP group than in the control group (P = 0.017, P = 0.046, P = 0.0029 and P 2 and postmenopausal women who carried the G/C + C/C genotype in the MMP‐10 gene had an increased risk of POP. Conclusion We support the view that the rs17435959 polymorphism of the MMP‐10 gene may be associated with an increased risk of POP.