Radiation dose and checkpoint blockade immunotherapy: unanswered questions

For various reasons, extrapolation of radiation dose effects from animal to human studies is not straightforward, not least of which being the exponential absolute differences in numbers of irradiated cells. [...]unlike human patients, animals are seldom irradiated every day for a period of weeks be...

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Veröffentlicht in:	The lancet oncology 2016, Vol.17 (1), p.e3-e4
Hauptverfasser:	Monjazeb, Arta M, Schoenfeld, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Cancer therapies Cell death Chemoradiotherapy - methods Granulocytes Hematology, Oncology and Palliative Medicine Humans Immune checkpoint Immunotherapy Immunotherapy - methods Melanoma Metastasis Neoplasms - therapy Radiation therapy Radiation Tolerance Radiation-Sensitizing Agents - therapeutic use Signal Transduction - drug effects Signal Transduction - radiation effects
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Zusammenfassung:	For various reasons, extrapolation of radiation dose effects from animal to human studies is not straightforward, not least of which being the exponential absolute differences in numbers of irradiated cells. [...]unlike human patients, animals are seldom irradiated every day for a period of weeks because of logistical and cost issues. [...]dose per fraction might, in many studies, serve as a proxy for total dose and overall levels of cell death.
ISSN:	1470-2045 1474-5488
DOI:	10.1016/S1470-2045(15)00541-0