RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer

In previous studies, we identified rhomboid domain containing 2 ( RHBDD2 ) gene to be markedly overexpressed in breast cancer patients that developed recurrence of the disease. In this study, we evaluated for the first time RHBDD2 gene expression in colorectal cancer (CRC). Five public available DNA...

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Veröffentlicht in:	Tumor biology 2012-12, Vol.33 (6), p.2393-2399
Hauptverfasser:	Lacunza, Ezequiel, Canzoneri, R., Rabassa, M. E., Zwenger, A., Segal-Eiras, A., Croce, M. V., Abba, M. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Case-Control Studies Chemotherapy Colon - metabolism Colon - pathology Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Fluorouracil - therapeutic use Gene expression Gene Expression Profiling Humans Immunoenzyme Techniques Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Staging Oligonucleotide Array Sequence Analysis Prognosis Real-Time Polymerase Chain Reaction Rectum - metabolism Rectum - pathology Research Article Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured
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Zusammenfassung:	In previous studies, we identified rhomboid domain containing 2 ( RHBDD2 ) gene to be markedly overexpressed in breast cancer patients that developed recurrence of the disease. In this study, we evaluated for the first time RHBDD2 gene expression in colorectal cancer (CRC). Five public available DNA microarray studies were compiled in a homogeneous dataset of 906 colorectal samples. The statistical analysis of these data showed a significant increase of RHBDD2 expression in the advanced stages of CRC ( p
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-012-0503-3