Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice

Highlights • Pretreatment of GLP-2 prevented the development of memory impairment induced by LPS. • >GLP-2 improved the LPS-induced memory impairment. • >GLP-2 showed weak anxiolytic-like effects in ACTH-treated, but not saline-treated mice. • >GLP-2 increased 5-HT, but not 5-HIAA levels in...

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Veröffentlicht in:	Neuropeptides (Edinburgh) 2015-02, Vol.49, p.7-14
Hauptverfasser:	Iwai, Takashi, Jin, Kazushi, Ohnuki, Tomoko, Sasaki-Hamada, Sachie, Nakamura, Minami, Saitoh, Akiyoshi, Sugiyama, Azusa, Ikeda, Masaatsu, Tanabe, Mitsuo, Oka, Jun-Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Adrenocorticotropic Hormone - administration & dosage Advanced Basic Science Animals Anti-Anxiety Agents - administration & dosage Antidepressant Anxiety Anxiety - drug therapy Brain - drug effects Brain - metabolism Brain Chemistry - drug effects Elevated plus-maze Endocrinology & Metabolism Glucagon-Like Peptide 2 - administration & dosage Glucagon-like peptide-2 Lipopolysaccharides Major depression Male Memory - drug effects Mice Motor Activity - drug effects Serotonin Serotonin - analysis Y-maze
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Zusammenfassung:	Highlights • Pretreatment of GLP-2 prevented the development of memory impairment induced by LPS. • >GLP-2 improved the LPS-induced memory impairment. • >GLP-2 showed weak anxiolytic-like effects in ACTH-treated, but not saline-treated mice. • >GLP-2 increased 5-HT, but not 5-HIAA levels in amygdala. • GLP-2 influenced memory functions and had anxiolytic effects via the 5-HT system.
ISSN:	0143-4179 1532-2785
DOI:	10.1016/j.npep.2014.11.001